Getting to the root of miRNA-Mediated gene silencing

被引：897

作者：

Eulalio, Ana ^{[1
]}

Huntzinger, Eric ^{[1
]}

Izaurralde, Elisa ^{[1
]}

机构：

[1] Max Planck Inst Dev Biol, D-72077 Tubingen, Germany

来源：

CELL | 2008年 / 132卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.12.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs are similar to 22 nucleotide-long RNAs that silence gene expression posttranscriptionally by binding to the 3' untranslated regions of target mRNAs. Although much is known about their biogenesis and biological functions, the mechanisms allowing miRNAs to silence gene expression in animal cells are still under debate. Here, we discuss current models for miRNA-mediated gene silencing and formulate a hypothesis to reconcile differences.

引用

页码：9 / 14

页数：6

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