Asymmetric synthesis of moiramide B

被引：20

作者：

Dixon, DJ ^{[1
]}

Davies, SG ^{[1
]}

机构：

[1] UNIV OXFORD,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 15期

关键词：

D O I：

10.1039/cc9960001797

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first asymmetric synthesis. of Moiranide B 1 is achieved using lithium amide 4 and pyrrolidinone auxiliary 5; pyrrolidinone auxiliary 5 is used to create the novel (S)-2-methyl-N-benzyloxysuccinimide 15 which is subsequently acylated with the highly,reactive tert-butoxycarbonyl-protected N-carboxanhydride of L-valine(Boc-Val-NCA) under strongly basic conditions, without racemization, while lithium amide 4 is used to synthesize homochiral D-beta-phenylalanine tert-butyl ester 8.

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页码：1797 / 1798

页数：2

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