Gene mutations responsible for overexpression of AmpC β-lactamase in some clinical isolates of Enterobacter cloacae

被引：54
作者：
Kaneko, K
Okamoto, R
Nakano, R
Kawakami, S
Inoue, M
机构：
[1] Kitasato Univ, Grad Sch Med Sci, Dept Environm Infect Dis, Sagamihara, Kanagawa 2288555, Japan
[2] Kitasato Univ, Sch Med, Dept Microbiol, Sagamihara, Kanagawa 2288555, Japan
[3] Teikyo Univ, Sch Med, Dept Cent Lab, Itabashi Ku, Tokyo, Japan
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2005年 / 43卷 / 06期
关键词：
D O I：
10.1128/JCM.43.6.2955-2958.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
AmpC regulatory genes in 21 ceftazidime-resistant clinical isolates of Enterobacter cloacae (MICs of >= 16 mu g/ml) were characterized. All isolates exhibited AmpC overproduction due to AmpD mutation. Additionally, we found two AmpR mutants among the isolates. This is the first report of chromosomal ampR mutation in clinical isolates of E. cloacae.
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页码：2955 / 2958
页数：4
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