Clinical Characteristics and Prognostic Factors of Gastroenteropancreatic Neuroendocrine Tumors: A Single Center Experience in China

被引:5
|
作者
Hu, Han-kui [1 ]
Ke, Neng-wen [1 ]
Li, Ang [1 ]
Du, Xiao-jiong [1 ]
Guo, Qiang [1 ]
Hu, Wei-ming [1 ]
机构
[1] Sichuan Univ, Dept Hepatobiliary Pancreat Surg, West China Hosp, Chengdu 610041, Peoples R China
关键词
Gastroenteropancreatic neuroendocrine tumors; Clinical characteristics; Prognostic factors; LIVER-TRANSPLANTATION; CARCINOID-TUMORS; ENDOCRINE TUMORS; GEP-NETS; SURVIVAL; EPIDEMIOLOGY; MULTICENTER; ETOPOSIDE; DIAGNOSIS; PANCREAS;
D O I
10.5754/hge13914
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aims: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a unique subgroup of tumors in the digestive system but with great clinical heterogeneity The information on clinical characteristics and prognostic factors of Chinese patients is rather limited. Methodology: We retrospectively analyzed the clinical features, prognostic factors of this disease in a consecutive cohort (N=294) between January 2007 and December 2012. Results: Functioning tumors accounted for 9.2%. Rectum was the most predominant GEP-NETs locations. Abdominal pain occurred in 46.5% patients which was the most common initial symptom. G1, G2 and G3 tumors accounted for 41.5%, 34.7% and 23.8%, respectively. Endoscopy provided the highest detection rate of 95.7%. Consistence between endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNAB) and surgically obtained histological Ki-67 index was 36.4%. Serum CgA test showed a 80.0% consistence with the tissue biopsy. The median follow up duration was 2.8 years (0.02-5.90years), the median survival was 4.8 years, overall 5-year survival rate was 69.6%. We found colonic localization, tumor size larger than 20 mm, G3 tumor and metastasis were associated with worse outcome(p<0.05). Conclusion: We found both consistence and differences in GEP-NETs characteristics between our study and previous reports.
引用
收藏
页码:178 / 183
页数:6
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