C-H Cyanoalkylation:the direct C-H Cyanomethylation of Naphthalimide

The cyanoalkylation/ cyanomethylation of organic molecules is of great research interest to organic and medicinal chemists due to the wide presence of the cyano group in biologically active molecules and the facile conversion of the cyano group into many other functional groups, such as amides, esters, aldehydes, and primary amines. Although a variety of different synthetic strategies have been developed for the selective introduction of the cyanomethyl group, an attractive approach is to use acetonitrile directly through C-H activation due to the highly efficient atom economy and the avoidance of prefunctionalization. Therefore, this review summarizes the main research progress in C-H cyanoalkylation/ cyanomethylation of radical cyanomethylation, Photochemical Cross over line coupling reaction, Cross over line Dehydrogenative Coupling ( CDC) Reaction, Directing group over line promoted C-H cyanomethylation and Fluorophore C-H cyanomethylation reported by our group.