Background Previous researches have shown that anesthetic techniques can influence the patient outcomes of cancer surgery. Here, we studied the relationship between type of anesthetic and patient outcomes following elective, open pancreatic cancer surgery. Methods This was a retrospective cohort study of patients who received elective, open pancreatic cancer surgery between January 2005 and July 2018. Patients were grouped according to the anesthesia they received, namely desflurane or propofol. A Kaplan-Meier analysis was conducted, and survival curves were presented from the date of surgery to death. Univariable and multivariable Cox regression models were used to compare hazard ratios for death after propensity matching. Subgroup analyses were performed for all-cause mortality, cancer-specific mortality, and disease progression. Results A total of 68 patients (56 deaths, 82.0%) under desflurane anesthesia, and 72 patients (43 deaths, 60.0%) under propofol anesthesia were included. Fifty-eight patients remained in each group after propensity matching. The propofol anesthesia was associated with improved survival (hazard ratio, 0.65; 95% confidence interval, 0.42-0.99; P = 0.047) in the matched analysis. Subgroup analyses showed significantly better cancer-specific survival (hazard ratio, 0.63; 95% confidence interval, 0.40-0.97; P = 0.037) in the propofol group. Additionally, patients under propofol had less postoperative recurrence, but not fewer postoperative metastases formation, than those under desflurane (hazard ratio, 0.55; 95% confidence interval, 0.34-0.90; P = 0.028) in the matched analysis. Conclusions In a limited sample size, we observed that propofol anesthesia was associated with improved survival in open pancreatic cancer surgery compared with desflurane anesthesia. Further investigations are needed to inspect the influences of propofol anesthesia on patient outcomes of pancreatic cancer surgery.
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Baba, Yoshifumi
Nosho, Katsuhiko
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Nosho, Katsuhiko
Shima, Kaori
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Shima, Kaori
Irahara, Natsumi
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Irahara, Natsumi
Chan, Andrew T.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Chan, Andrew T.
Meyerhardt, Jeffrey A.
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Meyerhardt, Jeffrey A.
Chung, Daniel C.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Chung, Daniel C.
Giovannucci, Edward L.
论文数: 0引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA
Harvard Univ, Sch Publ Hlth, Dept Epidemiol & Nutr, Boston, MA 02115 USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Giovannucci, Edward L.
Fuchs, Charles S.
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
机构:
Maimonides Hosp, Dept Surg, Brooklyn, NY 11219 USA
St Barnabas Hosp, Dept Surg, 94 Old Short Hills Rd, Livingston, NJ 07039 USAMaimonides Hosp, Dept Surg, Brooklyn, NY 11219 USA
Ballehaninna, Umashankar K.
Chamberlain, Ronald S.
论文数: 0引用数: 0
h-index: 0
机构:
St Barnabas Hosp, Dept Surg, 94 Old Short Hills Rd, Livingston, NJ 07039 USA
Univ Med & Dent New Jersey, Dept Surg, Newark, NJ 07103 USA
St Georges Univ, Sch Med, True Blue, Grenada
Univ Med & Dent New Jersey, Surg, Newark, NJ 07103 USAMaimonides Hosp, Dept Surg, Brooklyn, NY 11219 USA
机构:
Univ Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Univ Utah, Sch Med, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Call, Tyler R.
Pace, Nathan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Anesthesiol, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Pace, Nathan L.
Thorup, Datus B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Thorup, Datus B.
Maxfield, Derric
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Anesthesiol, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Maxfield, Derric
Chortkoff, Ben
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Chortkoff, Ben
Christensen, Joslin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Surg, Hunstman Canc Hosp, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Christensen, Joslin
Mulvihill, Sean J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Surg, Hunstman Canc Hosp, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Anesthesiol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Chen, Xiangyuan
Wu, Qichao
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Anesthesiol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Wu, Qichao
You, Li
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
You, Li
Chen, Sisi
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Xuzhou, Jiangsu, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Chen, Sisi
Zhu, Minmin
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Zhu, Minmin
Miao, Changhong
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Baba, Yoshifumi
Nosho, Katsuhiko
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Nosho, Katsuhiko
Shima, Kaori
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Shima, Kaori
Irahara, Natsumi
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Irahara, Natsumi
Chan, Andrew T.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Chan, Andrew T.
Meyerhardt, Jeffrey A.
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Meyerhardt, Jeffrey A.
Chung, Daniel C.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Gastrointestinal Unit, Boston, MA 02114 USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Chung, Daniel C.
Giovannucci, Edward L.
论文数: 0引用数: 0
h-index: 0
机构:
Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA
Harvard Univ, Sch Publ Hlth, Dept Epidemiol & Nutr, Boston, MA 02115 USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Giovannucci, Edward L.
Fuchs, Charles S.
论文数: 0引用数: 0
h-index: 0
机构:
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
Brigham & Womens Hosp, Channing Lab, Dept Med, Boston, MA 02115 USA
Harvard Univ, Sch Med, Dept Med Oncol, Boston, MA USADana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA
机构:
Maimonides Hosp, Dept Surg, Brooklyn, NY 11219 USA
St Barnabas Hosp, Dept Surg, 94 Old Short Hills Rd, Livingston, NJ 07039 USAMaimonides Hosp, Dept Surg, Brooklyn, NY 11219 USA
Ballehaninna, Umashankar K.
Chamberlain, Ronald S.
论文数: 0引用数: 0
h-index: 0
机构:
St Barnabas Hosp, Dept Surg, 94 Old Short Hills Rd, Livingston, NJ 07039 USA
Univ Med & Dent New Jersey, Dept Surg, Newark, NJ 07103 USA
St Georges Univ, Sch Med, True Blue, Grenada
Univ Med & Dent New Jersey, Surg, Newark, NJ 07103 USAMaimonides Hosp, Dept Surg, Brooklyn, NY 11219 USA
机构:
Univ Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Univ Utah, Sch Med, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Call, Tyler R.
Pace, Nathan L.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Anesthesiol, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Pace, Nathan L.
Thorup, Datus B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Sch Med, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Thorup, Datus B.
Maxfield, Derric
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Anesthesiol, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Maxfield, Derric
Chortkoff, Ben
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Chortkoff, Ben
Christensen, Joslin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Surg, Hunstman Canc Hosp, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
Christensen, Joslin
Mulvihill, Sean J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Utah, Dept Surg, Hunstman Canc Hosp, Salt Lake City, UT 84132 USAUniv Utah, Huntsman Canc Hosp, Dept Anesthesiol, Salt Lake City, UT 84132 USA
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Anesthesiol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Chen, Xiangyuan
Wu, Qichao
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Anesthesiol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Wu, Qichao
You, Li
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
You, Li
Chen, Sisi
论文数: 0引用数: 0
h-index: 0
机构:
Xuzhou Med Univ, Xuzhou, Jiangsu, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Chen, Sisi
Zhu, Minmin
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Zhu, Minmin
Miao, Changhong
论文数: 0引用数: 0
h-index: 0
机构:
Fudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China
Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R ChinaFudan Univ, Shanghai Canc Ctr, Dept Anaesthesiol, Shanghai, Peoples R China