Growth of Newcastle disease virus in chicken macrophages

被引：18

作者：

Lam, KM

机构：

[1] Dept. Population Health Reproduction, School of Veterinary Medicine, University of California, Davis

来源：

JOURNAL OF COMPARATIVE PATHOLOGY | 1996年 / 115卷 / 03期

关键词：

D O I：

10.1016/S0021-9975(96)80083-1

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Chicken macrophages were isolated from chicken peripheral blood, cultured in vitro, and infected with Newcastle disease virus (NDV) after reaching semi-confluence. Infected macrophages supported the growth and replication of NDV. Virus-infected macrophages exhibited features of apoptosis as determined by agarose gel electrophoresis, thymidine release assays and flow cytometry. Electron microscopical examination also showed the appearance of intact virus particles, fragmented chromatin and apoptotic bodies. This evidence demonstrates that NDV infection of chicken macrophages causes chicken macrophages to undergo apoptosis. (C) 1996 W.B. Saunders Company Limited

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收藏

页码：253 / 263

页数：11

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