High-performance liquid chromatography of α-amino acid enantiomers on eremomycin-modified silica

被引：31

作者：

Kuznetsov, M. A. ^{[1
]}

Nesterenko, P. N. ^{[1
]}

Vasiyarov, G. G. ^{[2
]}

Staroverov, S. M. ^{[1
,2
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia

[2] ZAO BioKhimMak ST, Moscow 119992, Russia

来源：

JOURNAL OF ANALYTICAL CHEMISTRY | 2008年 / 63卷 / 01期

关键词：

D O I：

10.1134/S1061934808010115

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The chromatographic behavior of enantiomers of alpha-amino acids was studied on new chiral stationary phases based on silica gel with macrocyclic glycopeptide antibiotic eremomycin and its aglycone immobilized on the surface. The retention of adsorbates and enantioselectivity of their separation were studied as functions of the structure of the side group of alpha-amino acids, eluant pH, concentration of organic modifier in the eluant, and temperature. The mechanism of the chiral recognition of alpha-amino acid enantiomers is discussed.

引用

页码：57 / 64

页数：8

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