Predictive and prognostic value of circulating tumor cell detection in lung cancer: A clinician's perspective

被引：30

作者：

Tognela, Annette ^{[1
,3
,5
,6
]}

Spring, Kevin J. ^{[1
,3
,4
]}

Becker, Therese ^{[1
,3
,4
]}

Caixeiro, Nicole J. ^{[1
,3
]}

Bray, Victoria J. ^{[2
]}

Yip, Po Yee ^{[6
,7
]}

Chua, Wei ^{[2
,3
]}

Lim, Stephanie H. ^{[1
,2
,3
,4
]}

De Souza, Paul ^{[1
,2
,3
,4
,5
]}

机构：

[1] Ingham Inst Appl Med Res, Med Oncol Grp, Liverpool 2170, Australia

[2] Liverpool Hosp, Dept Med Oncol, Liverpool 2170, Australia

[3] South West Sydney Translat Canc Res Unit, Liverpool 2170, Australia

[4] Univ New S Wales, Sch Med, Kensington, NSW 2052, Australia

[5] Univ Western Sydney, Macarthur Clin Sch, Campbelltown, NSW 2560, Australia

[6] Campbelltown Hosp, Dept Med Oncol, Campbelltown, NSW 2560, Australia

[7] Univ Sydney, Sydney Med Sch, Camperdown, NSW 2006, Australia

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2015年 / 93卷 / 02期

关键词：

Biomarkers; Non-small cell; Small cell; Circulating tumor cells; Lung cancer; POLYMERASE-CHAIN-REACTION; ASSISTED THORACIC-SURGERY; PULMONARY VENOUS-BLOOD; TRANSCRIPTION FACTOR-I; PERIPHERAL-BLOOD; MESSENGER-RNA; SURGICAL MANIPULATION; PROTEIN EXPRESSION; MOLECULAR-BIOLOGY; SURVIVAL;

D O I：

10.1016/j.critrevonc.2014.10.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is increasing evidence for the use of circulating tumor cells (CTCs) as a "liquid biopsy" for early detection of lung cancer recurrence, prognosticating disease and monitoring treatment response. Further, CTC molecular analysis and interrogation of single cells hold significant potential in providing insights into tumor biology and the metastatic process. Ongoing research will likely see the translation of CTCs as a prognostic and predictive biomarker in both small cell, and non-small cell, lung cancer to routine clinical practice. Crown Copyright (C) 2014 Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：90 / 102

页数：13

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