Systemic lupus erythematosus in patients with sickle cell disease

被引：15

作者：

Appenzeller, Simone ^{[1
,2
]}

Fattori, Andre ^{[3
]}

Saad, Sarita T. ^{[3
]}

Costallat, Lilian T. L. ^{[2
]}

机构：

[1] Univ Estadual Campinas, Fac Ciencias Med, Dept Clin Med, Disciplina Reumatol, BR-13081970 Campinas, SP, Brazil

[2] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Rheumatol Unit, Campinas, Brazil

[3] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Hematol Unit, Campinas, Brazil

来源：

CLINICAL RHEUMATOLOGY | 2008年 / 27卷 / 03期

关键词：

sickle cell disease; systemic lupus erythematosus;

D O I：

10.1007/s10067-007-0779-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sickle cell disease (SCD) is a prevalent genetic disorder that includes sickle cell anemia (hemoglobin SS), hemoglobin SC, and hemoglobin Sb-thalassemia. Patients with SCD present with a defective activation of the alternate pathway of the complement system that increases the risk of capsulate bacteria infection and failure to eliminate antigens, predisposing these patients to autoimmune diseases. The authors describe three patients with SCD that developed systemic lupus erythematosus (SLE). In all patients, SLE diagnosis was delayed because symptoms were initially attributable to SCD. Physicians should be alerted to the possible development of SLE in patients with SCD to not delay the diagnosis and start appropriate treatment.

引用

页码：359 / 364

页数：6

共 31 条

[11] Coexisting systemic lupus erythematosus and sickle cell disease a diagnostic and therapeutic challenge [J].