Pharmacotherapy for Pulmonary Arterial Hypertension

被引：2

作者：

Ramani, Gautam V. ^{[1
]}

Park, Myung H. ^{[2
]}

机构：

[1] Univ Maryland, Sch Med, Baltimore VAMC, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Cardiol Care Unit, Pulm Vasc Dis Program, Baltimore, MD 21201 USA

来源：

HEART FAILURE CLINICS | 2012年 / 8卷 / 03期

关键词：

Pulmonary arterial hypertension; Pulmonary hypertension; Pharmacotherapy; Prostacyclins; CONTINUOUS INTRAVENOUS EPOPROSTENOL; CALCIUM-CHANNEL BLOCKERS; LONG-TERM TREATMENT; INHALED ILOPROST; DOUBLE-BLIND; BOSENTAN THERAPY; PROSTACYCLIN THERAPY; SILDENAFIL CITRATE; OPEN-LABEL; TREPROSTINIL;

D O I：

10.1016/j.hfc.2012.04.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary arterial hypertension (PAH) is a disabling, progressive disease. The past decade has seen an explosion in the available therapies for the management of PAH. Choosing appropriate pharmacotherapy can be a daunting task for the practitioner, as no head-to-head comparisons between drugs have been published. This article aims to assist the practitioner in developing an evidence-based, rational pharmacologic treatment algorithm for the management of patients with PAH. Currently approved pharmacotherapy and the pivotal trials that led to approval for the respective agents are reviewed. Common dilemmas in the treatment of PAH for which strong evidence is lacking are discussed.

引用

页码：385 / +

页数：19

共 64 条

[1] Epoprostenol (prostacyclin) therapy in HIV-associated pulmonary hypertension [J].

Aguilar, RV ;

Farber, HW .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (05) :1846-1850

[2] Medical therapy for pulmonary arterial hypertension - Updated ACCP evidence-based clinical practice guidelines [J].

Badesch, David B. ;

Abman, Steven H. ;

Simonneau, Gerald ;

Rubin, Lewis J. ;

McLaughlin, Vallerie V. .

CHEST, 2007, 131 (06) :1917-1928

[3] Pulmonary Arterial Hypertension Baseline Characteristics From the REVEAL Registry [J].

Badesch, David B. ;

Raskob, Gary E. ;

Elliott, C. Greg ;

Krichman, Abby M. ;

Farber, Harrison W. ;

Frost, Adaani E. ;

Barst, Robyn. J. ;

Benza, Raymond L. ;

Liou, Theodore G. ;

Turner, Michelle ;

Giles, Scott ;

Feldkircher, Kathy ;

Miller, Dave P. ;

McGoon, Michael D. .

CHEST, 2010, 137 (02) :376-387

[4] Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease -: A randomized, controlled trial [J].

Badesch, DB ;

Tapson, VF ;

McGoon, MD ;

Brundage, BH ;

Rubin, LJ ;

Wigley, FM ;

Rich, S ;

Barst, RJ ;

Barrett, PS ;

Kral, KM ;

Jöbsis, MM ;

Loyd, JE ;

Murali, S ;

Frost, A ;

Girgis, R ;

Bourge, RC ;

Ralph, DD ;

Elliott, CG ;

Hill, NS ;

Langleben, D ;

Schilz, RJ ;

McLaughlin, VV ;

Robbins, IM ;

Groves, BM ;

Shapiro, S ;

Medsger, TA ;

Gaine, SP ;

Horn, E ;

Decker, JC ;

Knobil, K .

ANNALS OF INTERNAL MEDICINE, 2000, 132 (06) :425-+

[5]

Barst R., 2007, Morbidity and Mortality Weekly Report, V56, P170

[6] Long-term outcome in pulmonary arterial hypertension patients treated with subcutaneous treprostinil [J].

Barst, R. J. ;

Galie, N. ;

Naeije, R. ;

Simonneau, G. ;

Jeffs, R. ;

Arneson, C. ;

Rubin, L. J. .

EUROPEAN RESPIRATORY JOURNAL, 2006, 28 (06) :1195-1203

[7] A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension [J].

Barst, RJ ;

Rubin, LJ ;

Long, WA ;

McGoon, MD ;

Rich, S ;

Badesch, DB ;

Groves, BM ;

Tapson, VF ;

Bourge, RC ;

Brundage, BH ;

Koerner, SK ;

Langleben, D ;

Keller, CA ;

Murali, S ;

Uretsky, BF ;

Clayton, LM ;

Jobsis, MM ;

Blackburn, SD ;

Shortino, D ;

Crow, JW .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) :296-301

[8] Long-term effects of inhaled treprostinil in patients with pulmonary arterial hypertension: The TReprostinil sodium Inhalation Used in the Management of Pulmonary arterial Hypertension (TRIUMPH) study open-label extension [J].

Benza, Raymond L. ;

Seeger, Werner ;

McLaughlin, Vallerie V. ;

Channick, Richard N. ;

Voswinckel, Robert ;

Tapson, Victor F. ;

Robbins, Ivan M. ;

Olschewski, Horst ;

Rubin, Lewis J. .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2011, 30 (12) :1327-1333

[9] PRIMARY PULMONARY-HYPERTENSION - A HISTOPATHOLOGIC STUDY OF 80 CASES [J].

BJORNSSON, J ;

EDWARDS, WD .

MAYO CLINIC PROCEEDINGS, 1985, 60 (01) :16-25

[10] SURVIVAL IN PATIENTS WITH PRIMARY PULMONARY-HYPERTENSION - RESULTS FROM A NATIONAL PROSPECTIVE REGISTRY [J].

DALONZO, GE ;

BARST, RJ ;

AYRES, SM ;

BERGOFSKY, EH ;

BRUNDAGE, BH ;

DETRE, KM ;

FISHMAN, AP ;

GOLDRING, RM ;

GROVES, BM ;

KERNIS, JT ;

LEVY, PS ;

PIETRA, GG ;

REID, LM ;

REEVES, JT ;

RICH, S ;

VREIM, CE ;

WILLIAMS, GW ;

WU, M .

ANNALS OF INTERNAL MEDICINE, 1991, 115 (05) :343-349

← 1 2 3 4 5 6 7 →