Tumor-Stroma Interactions: Focus on Fibroblasts

被引：2
作者：
Gullberg, Donald [1 ]
Reed, Rolf K. [1 ]
机构：
[1] Univ Bergen, Dept Biomed, Bergen, Norway
来源：
MOUSE AS A MODEL ORGANISM: FROM ANIMALS TO CELLS | 2011年
关键词：
LUNG-CANCER CELLS; GROWTH-FACTOR; EXTRACELLULAR-MATRIX; GENE-EXPRESSION; BREAST-CANCER; COLORECTAL-CANCER; GASTRIC-CARCINOMA; MUTANT P53; STEM-CELLS; INTEGRIN;
D O I：
10.1007/978-94-007-0750-4_7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Despite improved diagnosis and therapies, including chemo- and radiotherapy, cancer still is among the leading causes of death in Europe and the world. Not only the tumor itself, but also the stromal tumor microenvironment has recently been pinpointed as a crucial player in tumor progression. Among the molecules of the tumor stroma, extracellular matrix components, integrins, matrix metalloproteinases and cytokines are considered potential targets in therapy approaches aimed at eradicating the tumor.
引用
收藏
页码：117 / 130
页数：14
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