Transforming growth factor β receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells

被引：15
作者：
Chattopadhyay, N
Tfelt-Hansen, J
Godbole, MM
Brown, EM
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Endocrinol Diabet & Hypertens, Boston, MA 02115 USA
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Membrane Biol Program, Boston, MA 02115 USA
[3] Sanjay Gandhi Postgrad Inst Med Sci, Dept Endocrinol, Lucknow 226014, Uttar Pradesh, India
来源：
MOLECULAR BRAIN RESEARCH | 2004年 / 121卷 / 1-2期
关键词：
activin-A; BMP; tumor; proliferation; angiogenesis;
D O I：
10.1016/j.molbrainres.2003.11.008
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Transforming growth factor (TGFbeta) and hepatocyte growth factor (HGF) promote glioma progression. Using U87human astrocytoma cells, which express TGFbeta receptors (TbetaRs), we show (1) mRNA expression of Smads (2, 3, 4), bone morphogenetic protein (BMP)- and activin-A receptors; (2) TGFbeta1 inhibits and HGF induces proliferation; (3) TGFbeta1 and activin-A equipotently inhibit HGF secretion more than BMP-2, but none alters c-Met expression. Because interfering with TbetaR signaling might nullify the beneficial inhibition of HGF secretion, activin-A should instead be considered for combination glioma therapy. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码：146 / 150
页数：5
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