Cisplatin binding to human serum albumin: a structural study

被引：111

作者：

Ferraro, Giarita ^{[1
]}

Massai, Lara ^{[2
]}

Messori, Luigi ^{[2
]}

Merlino, Antonello ^{[1
,3
]}

机构：

[1] Univ Naples Federico II, Dept Chem Sci, I-80126 Naples, Italy

[2] Univ Florence, Dept Chem, I-50019 Sesto Fiorentino, FI, Italy

[3] CNR Inst Biostruct & Bioimages, I-80126 Naples, Italy

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 46期

关键词：

X-RAY-STRUCTURE; SECONDARY STRUCTURE; MASS-SPECTROMETRY; CRYSTAL-STRUCTURE; IN-VITRO; PLATINUM; ANTICANCER; PROTEINS; ADDUCTS; CARBOPLATIN;

D O I：

10.1039/c5cc01751c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural data unambiguously prove that cisplatin mainly binds to His105 and Met329 side chains; additional binding sites are detected at His288, Met298, and Met548 and at His535, His67 and His247.

引用

收藏

页码：9436 / 9439

页数：4

相关论文

共 72 条

[1] Porous Protein Crystals as Reaction Vessels for Controlling Magnetic Properties of Nanoparticles [J].

Abe, Satoshi ;

Tsujimoto, Masahiko ;

Yoneda, Ko ;

Ohba, Masaaki ;

Hikage, Tatsuo ;

Takano, Mikio ;

Kitagawa, Susumu ;

Ueno, Takafumi .

SMALL, 2012, 8 (09) :1314-1319

[2] Platinum on the road: Interactions of antitumoral cisplatin with proteins [J].

Arnesano, Fabio ;

Natile, Giovanni .

PURE AND APPLIED CHEMISTRY, 2008, 80 (12) :2715-2725

[3] Binding of transition metal ions to albumin: Sites, affinities and rates [J].

Bal, Wojciech ;

Sokolowska, Magdalena ;

Kurowska, Ewa ;

Faller, Peter .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2013, 1830 (12) :5444-5455

[4] Interaction of Cisplatin with Human Superoxide Dismutase [J].

Banci, Lucia ;

Bertini, Ivano ;

Blazevits, Olga ;

Calderone, Vito ;

Cantini, Francesca ;

Mao, Jiafei ;

Trapananti, Angela ;

Vieru, Miguela ;

Amori, Ilaria ;

Cozzolino, Mauro ;

Carri, Maria Teresa .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2012, 134 (16) :7009-7014

[5] Binding of the general anesthetics propofol and halothane to human serum albumin - High resolution crystal structures [J].

Bhattacharya, AA ;

Curry, S ;

Franks, NP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (49) :38731-38738

[6] Structural investigation of cisplatin-protein interactions: Selective platination of His19 in a cuprozinc superoxide dismutase [J].

Calderone, V ;

Casini, A ;

Mangani, S ;

Messori, L ;

Orioli, PL .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (08) :1267-1269

[7]

Canal P, 1996, PLATINUM AND OTHER METAL COORDINATION COMPOUNDS IN CANCER CHEMOTHERAPY 2, P53

[8]

CARTER DC, 1994, ADV PROTEIN CHEM, V45, P153

[9] ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme [J].

Casini, Angela ;

Mastrobuoni, Guido ;

Temperini, Claudia ;

Gabbiani, Chiara ;

Francese, Simona ;

Moneti, Gloriano ;

Supuran, Claudiu T. ;

Scozzafava, Andrea ;

Messori, Luigi .

CHEMICAL COMMUNICATIONS, 2007, (02) :156-158

[10] Interactions of anticancer Pt compounds with proteins: an overlooked topic in medicinal inorganic chemistry? [J].

Casini, Angela ;

Reedijk, Jan .

CHEMICAL SCIENCE, 2012, 3 (11) :3135-3144

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