Rhodium(III)-Catalyzed One-Pot Cascade Synthesis of Functionalized Isoquinolines

被引：19
|
作者：
Wu, Xiao-Lin [1 ]
Dong, Lin [1 ]
机构：
[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, Chengdu 610041, Sichuan, Peoples R China
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 12期
关键词：
alkenes; rhodium; domino reactions; C-H activation; 2H-imidazoles; PALLADIUM-CATALYZED IMINOANNULATION; H BOND FUNCTIONALIZATION; REGIOSELECTIVE SYNTHESIS; EFFICIENT SYNTHESIS; AROMATIC KETIMINES; CARDIOTONIC AGENTS; COUPLING REACTIONS; NATURAL-PRODUCTS; 4+2 ANNULATION; ALKYNES;
D O I：
10.1002/ajoc.201800459
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly efficient Rh(III)-catalyzed one-pot reaction for the synthesis of functionalized alpha-carbonyl isoquinolines from 2H-imidazoles and alkenes has been successfully developed. This type of structure is constructed by using a transition-metal-catalyzed cascade: C-H bond activation, alkenylation, annulation, and hydrolysis.
引用
收藏
页码：2422 / 2426
页数：5
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