Post-ischemia mdivi-1 treatment protects against ischemia/reperfusion-induced brain injury in a rat model

被引：17

作者：

Ma, Xuesong ^{[1
,2
]}

Xie, Yuying ^{[1
]}

Chen, Yifan ^{[3
]}

Han, Baoqing ^{[1
]}

Li, Jun ^{[1
]}

Qi, Sihua ^{[1
]}

机构：

[1] Harbin Med Univ, Dept Anesthesiol, Affiliated Hosp 4, 37 Yiyuan St, Harbin 150001, Peoples R China

[2] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Peoples R China

[3] Fifth Hosp Harbin, Dept Nephrol, 27 Jiankang Rd, Harbin 150001, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2016年 / 632卷

关键词：

Ischemia/reperfusion; Mitochondrial fission; Mitochondrial division inhibitor-1 (mdivi-1); Mitochondrial biogenesis; Peroxisome proliferator-activated receptor coactivator-1 alpha (PGC-1 alpha); ISCHEMIA-REPERFUSION INJURY; TRANSIENT CEREBRAL-ISCHEMIA; INDUCED MITOCHONDRIAL FISSION; DYNAMIN-RELATED PROTEIN-1; ARTERY OCCLUSION; CYTOCHROME-C; CELL-DEATH; BIOGENESIS; DRP1; INHIBITION;

D O I：

10.1016/j.neulet.2016.08.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

When given prior to brain ischemia, mitochondrial division inhibitor-1 (mdivi-1) attenuates the brain damage caused by ischemia. Here, we investigated the potential effects of post-ischemia mdivi-1 treatment (1 mg/kg, i.p., administered immediately after 2 h of ischemia and prior to reperfusion) using a MCAO rat model. Mdivi-1 treatment decreased infarct volume and improved neurological function. In addition, cytochrome C release was attenuated, and neuronal apoptosis was decreased. The mitochondrial fission protein dynamin-related protein 1 (Drp1) was decreased in the mitochondrial fraction but increased in the cytosolic fraction. Mdivi-1 treatment augmented the increases in the mRNA expression of peroxisome proliferator-activated receptor coactivator-1 alpha, nuclear respiratory factor-1, and mitochondrial transcriptional factor A. In conclusion, when given after ischemia and prior to reperfusion, mdivi-1 can protect against brain damage by inhibiting the mitochondria-mediated apoptosis induced by mitochondrial fission. Post-ischemia mdivi-1 treatment might promote I/R-induced mitochondria( biogenesis. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：23 / 32

页数：10

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