An immunological link between Candida albicans colonization and Crohn's disease

被引：42

作者：

Gerard, Romain ^{[1
,2
,3
,4
,6
]}

Sendid, Boualem ^{[1
,2
,3
,5
,6
]}

Colombel, Jean-Frederic ^{[1
,2
,3
,4
,6
]}

Poulain, Daniel ^{[1
,2
,3
,5
,6
]}

Jouault, Thierry ^{[1
,2
,3
]}

机构：

[1] Univ Lille Nord France, F-59000 Lille, France

[2] UDSL, F-59000 Lille, France

[3] Team 2, Inserm U995, F-59000 Lille, France

[4] Serv Malad Appareil Digestif & Nutr, F-59000 Lille, France

[5] Inst Microbiol, Serv Parasitol Mycol, F-59000 Lille, France

[6] CHRU Lille, F-59000 Lille, France

来源：

CRITICAL REVIEWS IN MICROBIOLOGY | 2015年 / 41卷 / 02期

关键词：

Antigens; inflammation; innate/adaptive immune response; pathogen associated molecular patterns; SACCHAROMYCES-CEREVISIAE MANNAN; INFLAMMATORY-BOWEL-DISEASE; ANTIBODIES; AUTOPHAGY; RECOGNITION; SUSCEPTIBILITY; ASSOCIATION; RESPONSES; MARKERS; YEAST;

D O I：

10.3109/1040841X.2013.810587

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The etiology of Crohn's disease (CD), an autoimmune, inflammatory bowel disease (IBD) which affects approximately one million people in Europe, is still unclear. Nevertheless, it is widely accepted that CD could result from an inappropriate inflammatory response to intestinal microorganisms in a genetically susceptible host. Most studies to date have concerned the involvement of bacteria in disease progression. In addition to bacteria, there appears to be a possible link between the commensal yeast Candida albicans and disease development. In this review, in an attempt to link the gut colonization process and the development of CD, we describe the different pathways that are involved in the progression of CD and in the host response to C. albicans, making the yeast a possible initiator of the inflammatory process observed in this IBD.

引用

页码：135 / 139

页数：5

共 56 条

[1] MECHANISMS OF DISEASE Inflammatory Bowel Disease [J].

Abraham, Clara ;

Cho, Judy H. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (21) :2066-2078

[2] Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].

Barrett, Jeffrey C. ;

Hansoul, Sarah ;

Nicolae, Dan L. ;

Cho, Judy H. ;

Duerr, Richard H. ;

Rioux, John D. ;

Brant, Steven R. ;

Silverberg, Mark S. ;

Taylor, Kent D. ;

Barmada, M. Michael ;

Bitton, Alain ;

Dassopoulos, Themistocles ;

Datta, Lisa Wu ;

Green, Todd ;

Griffiths, Anne M. ;

Kistner, Emily O. ;

Murtha, Michael T. ;

Regueiro, Miguel D. ;

Rotter, Jerome I. ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Libioulle, Cecile ;

Sandor, Cynthia ;

Lathrop, Mark ;

Belaiche, Jacques ;

Dewit, Olivier ;

Gut, Ivo ;

Heath, Simon ;

Laukens, Debby ;

Mni, Myriam ;

Rutgeerts, Paul ;

Van Gossum, Andre ;

Zelenika, Diana ;

Franchimont, Denis ;

Hugot, Jean-Pierre ;

de Vos, Martine ;

Vermeire, Severine ;

Louis, Edouard ;

Cardon, Lon R. ;

Anderson, Carl A. ;

Drummond, Hazel ;

Nimmo, Elaine ;

Ahmad, Tariq ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Fisher, Sheila A. ;

Marchini, Jonathan ;

Ghori, Jilur .

NATURE GENETICS, 2008, 40 (08) :955-962

[3] Mycological aspects of gastrointestinal microflora [J].

Bernhardt, H ;

Knoke, M .

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1997, 32 :102-106

[4] Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [J].

Brand, S. .

GUT, 2009, 58 (08) :1152-1167

[5] Dectin-1 mediates the biological effects of β-glucans [J].

Brown, GD ;

Herre, J ;

Williams, DL ;

Willment, JA ;

Marshall, ASJ ;

Gordon, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (09) :1119-1124

[6] Immune recognition -: A new receptor for β-glucans [J].

Brown, GD ;

Gordon, S .

NATURE, 2001, 413 (6851) :36-37

[7] The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans [J].

Cheng, Shih-Chin ;

van de Veerdonk, Frank L. ;

Lenardon, Megan ;

Stoffels, Monique ;

Plantinga, Theo ;

Smeekens, Sanne ;

Rizzetto, Lisa ;

Mukaremera, Liliane ;

Preechasuth, Kanya ;

Cavalieri, Duccio ;

Kanneganti, Thirumala Devi ;

van der Meer, Jos W. M. ;

Kullberg, Bart Jan ;

Joosten, Leo A. B. ;

Gow, Neil A. R. ;

Netea, Mihai G. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2011, 90 (02) :357-366

[8] The genetics and immunopathogenesis of inflammatory bowel disease [J].

Cho, Judy H. .

NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :458-466

[9] The changing pattern of Crohn's disease incidence in northern France: a continuing increase in the 10-to 19-year-old age bracket (1988-2007) [J].

Chouraki, V. ;

Savoye, G. ;

Dauchet, L. ;

Vernier-Massouille, G. ;

Dupas, J. -L. ;

Merle, V. ;

Laberenne, J. -E. ;

Salomez, J. -L. ;

Lerebours, E. ;

Turck, D. ;

Cortot, A. ;

Gower-Rousseau, C. ;

Colombel, J. -F. .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2011, 33 (10) :1133-1142

[10] Secukinumab failure in Crohn's disease: the yeast connection? [J].

Colombel, Jean Frederic ;

Sendid, Boualem ;

Jouault, Thierry ;

Poulain, Daniel .

GUT, 2013, 62 (05) :800-801

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