Building the niche: The role of the S100 proteins in metastatic growth

被引：120
作者：
Lukanidin, Eugene [1 ]
Sleeman, Jonathan P. [2 ]
机构：
[1] Danish Canc Soc, Inst Canc Biol, Dept Tumor Microenvironm & Metastasis, Res Ctr, DK-2100 Copenhagen, Denmark
[2] Heidelberg Univ, Univ Med Mannheim, Ctr Biomed & Med Technol Mannheim CBTM, D-68167 Mannheim, Germany
来源：
SEMINARS IN CANCER BIOLOGY | 2012年 / 22卷 / 03期
关键词：
S100; family; Metastasis; Microenvironment; Metastatic niche; Inflammation; SERUM AMYLOID-A; COLONY-STIMULATING FACTOR; MYELOID CELL-DIFFERENTIATION; HYPOXIA-INDUCIBLE FACTOR-1; CALCIUM-BINDING PROTEINS; NECROSIS-FACTOR-ALPHA; BREAST-CANCER CELLS; ACUTE-PHASE PROTEIN; CD8(+) T-CELLS; NF-KAPPA-B;
D O I：
10.1016/j.semcancer.2012.02.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Communication between cancer cells and stromal cells, often mediated by extracellular molecules in the tumor microenvironment, plays a central role in tumorigenesis and metastasis. The establishment of a pro-inflammatory milieu is increasingly recognized as an important consequence of these interactions. The family of S100 Ca2+-binding proteins has been implicated in many aspects of the interaction between cancer cells and stromal cells, and contributes to the formation of an inflammatory tumor microenvironment. Focusing on S100A4, S100A8 and S100A9, in this review we discuss the role these proteins play in primary tumors and in the development of metastases, in particular during the formation of pre-metastatic niches. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：216 / 225
页数：10
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