Building the niche: The role of the S100 proteins in metastatic growth

被引：120

作者：

Lukanidin, Eugene ^{[1
]}

Sleeman, Jonathan P. ^{[2
]}

机构：

[1] Danish Canc Soc, Inst Canc Biol, Dept Tumor Microenvironm & Metastasis, Res Ctr, DK-2100 Copenhagen, Denmark

[2] Heidelberg Univ, Univ Med Mannheim, Ctr Biomed & Med Technol Mannheim CBTM, D-68167 Mannheim, Germany

来源：

SEMINARS IN CANCER BIOLOGY | 2012年 / 22卷 / 03期

关键词：

S100; family; Metastasis; Microenvironment; Metastatic niche; Inflammation; SERUM AMYLOID-A; COLONY-STIMULATING FACTOR; MYELOID CELL-DIFFERENTIATION; HYPOXIA-INDUCIBLE FACTOR-1; CALCIUM-BINDING PROTEINS; NECROSIS-FACTOR-ALPHA; BREAST-CANCER CELLS; ACUTE-PHASE PROTEIN; CD8(+) T-CELLS; NF-KAPPA-B;

D O I：

10.1016/j.semcancer.2012.02.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Communication between cancer cells and stromal cells, often mediated by extracellular molecules in the tumor microenvironment, plays a central role in tumorigenesis and metastasis. The establishment of a pro-inflammatory milieu is increasingly recognized as an important consequence of these interactions. The family of S100 Ca2+-binding proteins has been implicated in many aspects of the interaction between cancer cells and stromal cells, and contributes to the formation of an inflammatory tumor microenvironment. Focusing on S100A4, S100A8 and S100A9, in this review we discuss the role these proteins play in primary tumors and in the development of metastases, in particular during the formation of pre-metastatic niches. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：216 / 225

页数：10

共 197 条

[1] Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis
Al-Mehdi, AB
Tozawa, K
Fisher, AB
Shientag, L
Lee, A
Muschel, RJ
[J]. NATURE MEDICINE, 2000, 6 (01) : 100 - 102
[2] The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor
Ambartsumian, N
Klingelhöfer, J
Grigorian, M
Christensen, C
Kriajevska, M
Tulchinsky, E
Georgiev, G
Berezin, V
Bock, E
Rygaard, J
Cao, RH
Cao, YH
Lukanidin, E
[J]. ONCOGENE, 2001, 20 (34) : 4685 - 4695
[3] Ambartsumian NS, 1996, ONCOGENE, V13, P1621
[4] Andersen K, 1998, ANTICANCER RES, V18, P3299
[5] S100A8 and S100A9 overexpression is associated with poor pathological parameters in invasive ductal carcinoma of the breast
Arai, Kazumori
Takano, Sachiko
Teratani, Takumi
Ito, Yasuhiro
Yamada, Toshihiro
Nozawa, Ryushi
[J]. CURRENT CANCER DRUG TARGETS, 2008, 8 (04) : 243 - 252
[6] SERUM AMYLOID-A IS A CHEMOATTRACTANT - INDUCTION OF MIGRATION, ADHESION, AND TISSUE INFILTRATION OF MONOCYTES AND POLYMORPHONUCLEAR LEUKOCYTES
BADOLATO, R
WANG, JM
MURPHY, WJ
LLOYD, AR
MICHIEL, DF
BAUSSERMAN, LL
KELVIN, DJ
OPPENHEIM, JJ
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (01) : 203 - 209
[7] Cancer and the chemokine network
Balkwill, F
[J]. NATURE REVIEWS CANCER, 2004, 4 (07) : 540 - 550
[8] Inflammation and cancer: back to Virchow?
Balkwill, F
Mantovani, A
[J]. LANCET, 2001, 357 (9255) : 539 - 545
[9] Pathway-specific profiling identifies the NF-κB-dependent tumor necrosis factor α-regulated genes in epidermal keratinocytes
Banno, T
Gazel, A
Blumenberg, M
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (19) : 18973 - 18980
[10] Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth
Barkan, Dalit
Green, Jeffrey E.
Chambers, Ann F.
[J]. EUROPEAN JOURNAL OF CANCER, 2010, 46 (07) : 1181 - 1188

← 1 2 3 4 5 6 7 8 9 10 →