TCA cycle off, ATF4 on for metabolic homeostasis

被引：9

作者：

Mahor, Durga ^{[1
]}

Pandey, Rishikesh ^{[1
]}

Bulusu, Vinay ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Dept Biol Sci, ITI Tranet Campts, Berhampur 760010, Odisha, India

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2022年 / 47卷 / 07期

关键词：

FUMARATE;

D O I：

10.1016/j.tibs.2022.03.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox metabolic pathways.

引用

页码：558 / 560

页数：3