A Phytochemical Approach to Experimental Metabolic Syndrome-Associated Renal Damage and Oxidative Stress

被引：1

作者：

Marotta, Francesco ^{[1
]}

Kumari, Archana ^{[2
]}

Catanzaro, Roberto ^{[3
]}

Solimene, Umberto ^{[4
]}

Jain, Shalini ^{[5
]}

Minelli, Emilio ^{[4
]}

Harada, Masatoshi ^{[6
]}

机构：

[1] ReGenera Res Grp Aging Intervent, I-20154 Milan, Italy

[2] Univ Quebec, Inst Natl Rech Sci, Ctr Eau Terre & Environm, Quebec City, PQ, Canada

[3] Univ Catania, Dept Internal Med, Gastroenterol Unit, Catania, Italy

[4] Univ Milan, WHO Ctr Biotechnol & Tradit Med, Milan, Italy

[5] NIDDK, NIH, Bethesda, MD USA

[6] MCH Hosp, Saitama, Japan

来源：

REJUVENATION RESEARCH | 2012年 / 15卷 / 02期

关键词：

CARDIOVASCULAR-DISEASE; KIDNEY-DISEASE; FRUCTOSE; HYPERTENSION; NOTOGINSENG; MORTALITY; EXTRACTS;

D O I：

10.1089/rej.2011.1266

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The aim of this study was to evaluate the effect of DTS-phytocompound on oxidant-antioxidant balance and protein damage in the kidneys of rats administered high doses of fructose. Adult male Wistar rats were divided into four groups. Group A received a control diet, whereas groups B and C were fed a high-fructose diet (60 g/100 g), the latter with additional DTS (50 mg/kg per day) for 60 days. Lipo-and nitro-peroxidation together with alpha-smooth muscle actin (alpha-SMA) expression in the glomerular and interstitial tissue of the kidneys were measured after 60 days. Fructose-fed rats showed significantly higher lipoperoxidation, 2,4-dinitrophenol and 3-nitrotyrosine protein adducts, and upregulation of alpha-SMA in the kidney. DTS significantly decreased such redox unbalance in renal tissue, while partially downregulating alpha-SMA (p < 0.01). These data suggest the potential clinical benefit of DTS in protecting the kidneys from metabolic syndrome-associated changes; gender-related analysis is under way.

引用

页码：153 / 156

页数：4