Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer

被引：43
作者：
Burke, Lorraine [1 ,2 ]
Butler, Clare T. [1 ]
Murphy, Adrian [3 ]
Moran, Bruce [1 ]
Gallagher, William M. [1 ]
O'Sullivan, Jacintha [4 ]
Kennedy, Breandan N. [1 ]
机构：
[1] Univ Coll Dublin, UCD Conway Inst, UCD Sch Biomol & Biomed Sci, Dublin, Ireland
[2] Trinity Coll Dublin, St Jamess Hosp, Dept Surg, Translat Oncol,Trinity Translat Med Inst, Dublin, Ireland
[3] Johns Hopkins Univ Hosp, Dept Med Oncol, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21287 USA
[4] Trinity Coll Dublin, Dept Surg, Trinity Translat Med Inst, St Jamess Hosp, Dublin, Ireland
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2016年 / 4卷
关键词：
cysteinyl leukotriene; eicosanoid; colorectal cancer; tumorigenesis; hallmarks of cancer; cysteinyl leukotriene receptor antagonist; FACTOR-KAPPA-B; ACTIVATED PROTEIN-KINASE; GROWTH-FACTOR RECEPTOR; BETA-CATENIN; 1ST-LINE TREATMENT; CYSLT(1) RECEPTOR; POTENTIAL TARGET; CELL-MIGRATION; C-MYC; D-4;
D O I：
10.3389/fcell.2016.00103
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Colorectal cancer is the third most common cancer worldwide and is associated with significant morbidity and mortality. Current pharmacotherapy options include cytotoxic chemotherapy, anti-VEGF, and anti-EGFR targeting drugs, but these are limited by toxic side effects, limited responses and ultimately resistance. Cysteinyl leukotriene (CysLT) signaling regulates intestinal homeostasis with mounting evidence suggesting that CysLT signaling also plays a role in the pathogenesis of colorectal cancer. Therefore, CysLT signaling represents a novel target for this malignancy. This review evaluates reported links between CysLT signaling and established hallmarks of cancer in addition to its pharmacological potential as a new therapeutic target.
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页数：9
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