5′-Porphyrin-oligonucleotide conjugates:: Neutral porphyrin-DNA interactions

被引：42
|
作者：
Balaz, M [1 ]
Steinkruger, JD [1 ]
Ellestad, GA [1 ]
Berova, N [1 ]
机构：
[1] Columbia Univ, Dept Chem, New York, NY 10027 USA
来源：
ORGANIC LETTERS | 2005年 / 7卷 / 25期
关键词：
D O I：
10.1021/ol0522992
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Incorporation of hydrophilic tetraarylporphyrin phosphoramidites into the 5'-termimus of the DNA as well as noncharged porphyrin-DNA interactions have been studied. Porphyrin-modified oligonucleotides show lower melting temperatures than their unmodified analogues. Single-stranded DNA interacts more strongly with porphyrin and causes more intense chiral disturbance in the porphyrin environment than the corresponding double strand.
引用
收藏
页码：5613 / 5616
页数：4
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