Compound Danshen tablets downregulate amyloid protein precursor mRNA expression in a transgenic cell model of Alzheimer's disease Effects and a comparison with donepezil

被引：6

作者：

Qin, Ren'an ^{[2
]}

Zhou, Desheng ^{[1
]}

Wang, Jiajun ^{[1
]}

Hu, Hua ^{[1
]}

Yang, Yang ^{[1
]}

Yao, Xiaoxuan ^{[2
]}

Sun, Xiaopeng ^{[1
]}

机构：

[1] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Neurol, Changsha 410007, Hunan, Peoples R China

[2] Hutchison Whampoa Guangzhou Baiyunshan Chinese Me, Modern Chinese Med Res Inst, Guangzhou 510515, Guangdong, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 09期

关键词：

amyloid protein precursor; Alzheimer's disease; transgenic cell model; compound Danshen tablets; Chinese medicine; neural regeneration; APOPTOSIS;

D O I：

10.3969/j.issn.1673-5374.2012.09.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

After gene mutation, the pcDNA3.1/APP595/596 plasmid was transfected into HEK293 cells to establish a cell model of Alzheimer's disease. The cell model was treated with donepezil or compound Danshen tablets after culture for 72 hours. Reverse transcription-PCR showed that the mRNA expression of amyloid protein precursor decreased in all groups following culture for 24 hours, and that there was no significant difference in the amount of decrease between donepezil and compound Danshen tablets. Our results suggest that compound Danshen tablets can reduce expression of the mRNA for amyloid protein precursor in a transgenic cell model of Alzheimer's disease, with similar effects to donepezil.

引用

页码：659 / 663

页数：5

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