Overexpression of COX-2 and LMP1 are correlated with lymph node in Tunisian NPC patients

被引：14

作者：

Fendri, Ali ^{[1
]}

Khabir, Abdelmajid ^{[2
]}

Hadhri-Guiga, Boutheina ^{[1
]}

Sellami-Boudawara, Tahia ^{[2
]}

Ghorbel, Abdelmoonem ^{[2
]}

Daoud, Jamel ^{[2
]}

Frikha, Mounir ^{[2
]}

Jlidi, Rachid ^{[3
]}

Gargouri, Ali ^{[1
]}

Mokdad-Gargouri, Raja ^{[1
]}

机构：

[1] Ctr Biotechnol, Genet Mol Eucaryotes Lab, Sfax, Tunisia

[2] Univ Habib Bourguiba, Ctr Hosp, Sfax, Tunisia

[3] Lab Prive Anatomopathol, Sfax, Tunisia

来源：

ORAL ONCOLOGY | 2008年 / 44卷 / 07期

关键词：

cyclooxygenase-2; nasopharyngeal carcinoma; latent membrane protein 1; overexpression;

D O I：

10.1016/j.oraloncology.2007.09.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cyclooxygenase 2 (COX-2) an inducible form of COX is frequently up-regulated in many human tumours. The expression of COX-2 in nasopharyngeal carcinoma (NPC) and its relationship to clinicopathological features were studied in Tunisian patients. COX-2 mRNA was detected in 91% of tumour tissues. Immunohistochemical analysis showed that COX-2 protein was strongly detected in tumour cells and the staining was mainly cytoplasmic. In contrast, COX-2 mRNA and protein were very low or undetectable in normal. nasopharyngeal. mucosa. Our result showed a significant association of COX-2 overexpression with the lymph node involvement, however, no correlation was observed with age, tumour stage, histological type and distant metastasis. Moreover, we showed that all tumour specimens co-overexpressed COX-2 and the EBV oncoprotein LMP1 corroborating the fact that LPM1 is known to induce COX-2. Altogether, our data suggests that the COX-2 is overexpressed in NPC biopsies and that is linked to the Lymph node involvement. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：710 / 715

页数：6

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