Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice

被引：522
|
作者：
Park, Y [1 ]
Storkson, JM [1 ]
Albright, KJ [1 ]
Liu, W [1 ]
Pariza, MW [1 ]
机构：
[1] Univ Wisconsin, Food Res Inst, Dept Food Microbiol & Toxicol, Madison, WI 53706 USA
来源：
LIPIDS | 1999年 / 34卷 / 03期
关键词：
D O I：
10.1007/s11745-999-0358-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9, trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10, cis-12 isomer.
引用
收藏
页码：235 / 241
页数：7
相关论文
共 50 条
  • [41] Liver Carbohydrate and Lipid Metabolism of Insulin-Deficient Mice Is Altered by trans-10, cis-12 Conjugated Linoleic Acid
    Jourdan, Tony
    Djaouti, Louiza
    Demizieux, Laurent
    Gresti, Joseph
    Verges, Bruno
    Degrace, Pascal
    JOURNAL OF NUTRITION, 2009, 139 (10): : 1901 - 1907
  • [42] Evidence that commercial calf and horse sera can contain substantial amounts of trans-10,cis-12 conjugated linoleic acid
    Park, Y
    Pariza, MW
    LIPIDS, 1998, 33 (08) : 817 - 819
  • [43] Incorporation of cis-9, trans-11 or trans-10, cis-12 conjugated linoleic acid into human erythrocytes in vivo
    Burdge, GC
    Derrick, PR
    Russell, JJ
    Tricon, S
    Kew, S
    Banerjee, T
    Grimble, RF
    Williams, CM
    Yaqoob, P
    Calder, PC
    NUTRITION RESEARCH, 2005, 25 (01) : 13 - 19
  • [44] Regulation of stearoyl-CoA desaturase activity by the trans-10,cis-12 isomer of conjugated linoleic acid in HepG2 cells
    Choi, YJ
    Park, Y
    Pariza, MW
    Ntanbi, JM
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 284 (03) : 689 - 693
  • [45] Docosahexaenoic Acid and Eicosapentaenoic Acid Did not Alter trans-10,cis-12 Conjugated Linoleic Acid Incorporation into Mice Brain and Eye Lipids
    Vemuri, Madhuri
    Adkins, Yuriko
    Mackey, Bruce E.
    Kelley, Darshan S.
    LIPIDS, 2017, 52 (09) : 763 - 769
  • [46] Trans-10, cis-12 conjugated linoleic acid reduces milk fat synthesis in lactating goats.
    Rovai, M.
    Lock, A. L.
    Gipson, T. A.
    Goetsch, A. L.
    Bauman, D. E.
    JOURNAL OF ANIMAL SCIENCE, 2006, 84 : 294 - 294
  • [47] The trans-10,cis-12 isomer of conjugated linoleic acid enhances glucose transport in insulin-resistant rat skeletal muscle.
    Henriksen, EJ
    Teachey, MK
    Taylor, ZC
    Jacob, S
    Krämer, K
    Klatt, MJ
    Ptock, A
    Hasselwander, O
    DIABETOLOGIA, 2002, 45 : A228 - A228
  • [48] Trans-10,cis-12 conjugated linoleic acid decreases liver triacylglycerol content, but does not modify lipogenesis
    Zabala, A
    Churruca, I
    Navarro, V
    Macarulla, MT
    Fdez-Quintela, A
    Rodríguez, VM
    Martínez, JA
    Simón, E
    Portillo, MP
    INTERNATIONAL JOURNAL OF OBESITY, 2004, 28 : S76 - S76
  • [49] Trans-10, cis-12 conjugated linoleic acid decreases de novo lipid synthesis in human adipocytes
    Obsen, Thomas
    Faergeman, Nils J.
    Chung, Soonkyu
    Martinez, Kristina
    Gobern, Semone
    Loreau, Olivier
    Wabitsch, Martin
    Mandrup, Susanne
    McIntosh, Michael
    JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2012, 23 (06): : 580 - 590
  • [50] De novo synthesis of trans-10, cis-12 conjugated linoleic acid in oleaginous yeast Yarrowia Lipolytica
    Zhang, Baixi
    Rong, Chunchi
    Chen, Haiqin
    Song, Yuanda
    Zhang, Hao
    Chen, Wei
    MICROBIAL CELL FACTORIES, 2012, 11
12345