Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice

被引：522

作者：

Park, Y ^{[1
]}

Storkson, JM ^{[1
]}

Albright, KJ ^{[1
]}

Liu, W ^{[1
]}

Pariza, MW ^{[1
]}

机构：

[1] Univ Wisconsin, Food Res Inst, Dept Food Microbiol & Toxicol, Madison, WI 53706 USA

来源：

LIPIDS | 1999年 / 34卷 / 03期

关键词：

D O I：

10.1007/s11745-999-0358-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9, trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10, cis-12 isomer.

引用

页码：235 / 241

页数：7

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