Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice

被引：522
|
作者：
Park, Y [1 ]
Storkson, JM [1 ]
Albright, KJ [1 ]
Liu, W [1 ]
Pariza, MW [1 ]
机构：
[1] Univ Wisconsin, Food Res Inst, Dept Food Microbiol & Toxicol, Madison, WI 53706 USA
来源：
LIPIDS | 1999年 / 34卷 / 03期
关键词：
D O I：
10.1007/s11745-999-0358-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9, trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10, cis-12 isomer.
引用
收藏
页码：235 / 241
页数：7
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