Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice

被引：522
|
作者：
Park, Y [1 ]
Storkson, JM [1 ]
Albright, KJ [1 ]
Liu, W [1 ]
Pariza, MW [1 ]
机构：
[1] Univ Wisconsin, Food Res Inst, Dept Food Microbiol & Toxicol, Madison, WI 53706 USA
来源：
LIPIDS | 1999年 / 34卷 / 03期
关键词：
D O I：
10.1007/s11745-999-0358-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the effects of conjugated linoleic acid (CLA) preparations, which were enriched for the cis-9, trans-11 CLA isomer or the trans-10,cis-12 CLA isomer, on body composition in mice. Body composition changes (reduced body fat, enhanced body water, enhanced body protein, and enhanced body ash) were associated with feeding the trans-10,cis-12 CLA isomer. In cultured 3T3-L1 adipocytes, the trans-10,cis-12 isomer reduced lipoprotein lipase activity, intracellular triacylglycerol and glycerol, and enhanced glycerol release into the medium. By contrast, the cis-9,trans-11 and trans-9,trans-11 CLA isomers did not affect these biochemical activities. We conclude that CLA-associated body composition change results from feeding the trans-10, cis-12 isomer.
引用
收藏
页码：235 / 241
页数：7
相关论文
共 50 条
  • [1] The trans-10,cis-12 isomer of conjugated linoleic acid (CLA) induces body composition changes in mice
    Park, Y
    Storkson, JM
    Albright, KJ
    Liu, W
    Pariza, MW
    FASEB JOURNAL, 1999, 13 (05): : A875 - A875
  • [2] Effects of trans-10,cis-12 Conjugated Linoleic Acid on Body Composition in Genetically Obese Mice
    Hur, Sunjin
    Whitcomb, Faith
    Rhee, Siyeon
    Park, Yooheon
    Good, Deborah J.
    Park, Yeonhwa
    JOURNAL OF MEDICINAL FOOD, 2009, 12 (01) : 56 - 63
  • [3] Production of trans-10, cis-12 conjugated linoleic acid in rice
    Kohno-Murase, J
    Iwabuchi, M
    Endo-Kasahara, S
    Sugita, K
    Ebinuma, H
    Imamura, J
    TRANSGENIC RESEARCH, 2006, 15 (01) : 95 - 100
  • [4] Production of trans-10, cis-12 Conjugated Linoleic Acid in Rice
    Junko Kohno-Murase
    Mari Iwabuchi
    Saori Endo-Kasahara
    Koichi Sugita
    Hiroyasu Ebinuma
    Jun Imamura
    Transgenic Research, 2006, 15 : 95 - 100
  • [5] Adipose depletion and apoptosis induced by trans-10, cis-12 conjugated linoleic acid in mice
    Hargrave, KM
    Li, CL
    Meyer, BJ
    Kachman, SD
    Hartzell, DL
    Della-Fera, MA
    Miner, JL
    Baile, CA
    OBESITY RESEARCH, 2002, 10 (12): : 1284 - 1290
  • [6] Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse
    Clément, L
    Poirier, H
    Niot, I
    Bocher, V
    Guerre-Millo, M
    Krief, S
    Staels, B
    Besnard, P
    JOURNAL OF LIPID RESEARCH, 2002, 43 (09) : 1400 - 1409
  • [7] Effect of trans-10, cis-12 isomer of conjugated linoleic acid on boar semen quality after cryopreservation
    Pontes Teixeira, Sofia Margarida
    Nobre Chaveiro, Antonio Eduardo
    Moreira da Silva, Joaquim Fernando
    ANIMAL REPRODUCTION, 2017, 14 (02) : 400 - 405
  • [8] Dose response of milk fat to intravenous administration of the trans-10, cis-12 isomer of conjugated linoleic acid
    Viswanadha, S
    Giesy, JG
    Hanson, TW
    McGuire, MA
    JOURNAL OF DAIRY SCIENCE, 2003, 86 (10) : 3229 - 3236
  • [9] Effect of trans-10 cis-12 conjugated linoleic acid on Bovine Oocyte Competence and Fatty Acid Composition
    Lapa, M.
    Marques, C. C.
    Alves, S. P.
    Vasques, M. I.
    Baptista, M. C.
    Carvalhais, I.
    Pereira, M. Silva
    Horta, A. E. M.
    Bessa, R. J. B.
    Pereira, R. M.
    REPRODUCTION IN DOMESTIC ANIMALS, 2011, 46 (05) : 904 - 910
  • [10] Effect of trans-10, cis-12 conjugated linoleic acid on liver size and composition in adult hamsters
    Miranda, J.
    Navarro, V.
    Simon, E.
    Fernandez-Quintela, A.
    Churruca, I.
    Rodriguez, V. M.
    Portillo, M. P.
    ANNALS OF NUTRITION AND METABOLISM, 2007, 51 : 234 - 234
12345