Regeneratory Characteristics of Complex Extract and Isolated Diterpene Alkaloids of Aconitum baikalense

被引：14

作者：

Nesterova, Yu V. ^{[1
]}

Povetieva, T. N. ^{[1
]}

Suslov, N. I. ^{[1
]}

Zhdanov, V. V. ^{[1
]}

Hrichkova, T. Yu ^{[1
]}

Udut, E. V. ^{[1
]}

Chaykovskiy, A. S. ^{[1
]}

Gaydamovich, N. N. ^{[1
]}

Andreeva, T. I. ^{[1
]}

Dygai, A. M. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Siberian Div, Inst Pharmacol, Tomsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 152卷 / 04期

关键词：

plane skin wound; regeneration; fibroblast precursors; diterpene alkaloids;

D O I：

10.1007/s10517-012-1548-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effects of complex extract from Aconitum baikalense on reparative regeneration of a plane dorsal skin wound were studied. Treatment with Aconitum baikalense tincture stimulated reparation and skin regeneration. The effects of the Aconitum baikalense alkaloids on functional activity of fibroblast precursors were studied in vitro by cultural methods. Mesaconitine, hypaconitine, songorine, napelline, and 12-epinapelline N-oxide significantly stimulated the growth of colonies from fibroblast precursors. This indicated direct stimulation of fibroblasts by aconite alkaloids, which could be a mechanism of reparative activity of the complex extract.

引用

页码：439 / 443

页数：5

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