Mycobacterium indicus pranii protein MIP_05962 induces Th1 cell mediated immune response in mice

被引：9
|
作者：
Sharma, Ashish [1 ]
Saqib, Mohd. [2 ]
Sheikh, Javaid A. [3 ]
Ehtesham, Nasreen Z. [3 ]
Bhaskar, Sangeeta [2 ]
Chaudhuri, Tapan K. [1 ]
Hasnain, Seyed E. [1 ,4 ,5 ]
机构：
[1] Indian Inst Technol, Kusuma Sch Biol Sci, Hauz Khas, New Delhi 110016, India
[2] Natl Inst Immunol, Arena Asaf Ali Marg, New Delhi 110067, India
[3] Natl Inst Pathol, Safdarjung Hosp Campus, New Delhi 110029, India
[4] Jamia Hamdard, JH Inst Mol Med, New Delhi 110062, India
[5] Dr Reddys Inst Life Sci, Univ Hyderabad Campus,Prof CR Rao Rd, Hyderabad 500045, India
来源：
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2018年 / 308卷 / 08期
关键词：
Small heat shock proteins; Immunomodulation; CD4(+) cells; CD8(+)cells; Tuberculosis; Mycobacterium indicus pranii; Th1 immune response; TUMOR-NECROSIS-FACTOR; INTERFERON-GAMMA; IFN-GAMMA; PROTECTIVE EFFICACY; FACTOR-ALPHA; B-CELLS; TUBERCULOSIS; VACCINE; BCG; ANTIGEN;
D O I：
10.1016/j.ijmm.2018.08.008
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Utility of Mycobacterium indicus pranii (MIP) as a multistage vaccine against mycobacterial infections demands identification of its protective antigens. We explored antigenicity and immunogenicity of a candidate protein MIP_05962 that depicts homology to HSP18 of M. leprae and antigen' of Mycobacteriwn tuberculosis. This protein elicited substantial antibody response in immunized mice along with modulation of cellular immune response towards protective Thl type. Both CD4(+) and CD8(+) subsets from immunized mice produced hallmark protective cytokines,IFN-gamma, TNF-alpha and IL-2. This protein also enhanced the CD4(+) effector memory that could act as first line of defence during infections. These results point to MIP_05962 as a protective antigen that contributes, in conjunction with others, to the protective immunity of this live vaccine candidate.
引用
收藏
页码：1000 / 1008
页数：9
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