Structure activity relationship, in vitro and in vivo profile of JN403, a nAChR a7 selective agonist

被引：0
|
作者：
Nozulak, Joachim [1 ]
Hoyer, Daniel [1 ]
Chaperon, Frederique [1 ]
Lingenhoehl, Kurt [1 ]
Vassout, Annick [1 ]
Feuerbach, Dominik [1 ]
机构：
[1] Novartis Inst BioMed Res, Basel, Switzerland
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 242卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
370-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [31] In Vivo Structure-Activity Relationship Study of Dorsomorphin Analogues Identifies Selective VEGF and BMP Inhibitors
    Hao, Jijun
    Ho, Joshua N.
    Lewis, Jana A.
    Karim, Kaleh A.
    Daniels, R. Nathan
    Gentry, Patrick R.
    Hopkins, Corey R.
    Lindsley, Craig W.
    Hong, Charles C.
    ACS CHEMICAL BIOLOGY, 2010, 5 (02) : 245 - 253
  • [32] Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays
    Stoiljkovic, Milan
    Leventhal, Liza
    Chen, Angela
    Chen, Ting
    Driscoll, Rachelle
    Flood, Dorothy
    Hodgdon, Hilliary
    Hurst, Raymond
    Nagy, David
    Piser, Timothy
    Tang, Cuyue
    Townsend, Matthew
    Tu, Zhiming
    Bertrand, Daniel
    Koenig, Gerhard
    Hajos, Mihaly
    BIOCHEMICAL PHARMACOLOGY, 2015, 97 (04) : 576 - 589
  • [33] Structure activity relationship of hydantoins modulating the antitumor effects and toxicity of vinca alkaloids in vitro and in vivo.
    Ganapathi, R
    Lobert, S
    Correia, JJ
    Grabowski, D
    Kawamura, KI
    Bukowski, R
    CLINICAL CANCER RESEARCH, 2000, 6 : 4533S - 4533S
  • [34] In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: Identifying sinensetin as a novel antiangiogenesis agent
    Lam, In Kei
    Alex, Deepa
    Wang, You-Hua
    Liu, Ping
    Liu, Ai-Lin
    Du, Guan-Hua
    Lee, Simon Ming Yuen
    MOLECULAR NUTRITION & FOOD RESEARCH, 2012, 56 (06) : 945 - 956
  • [35] Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists
    Walker, Daniel P.
    Wishka, Donn G.
    Piotrowski, David W.
    Jia, Shaojuan
    Reitz, Steven C.
    Yates, Karen M.
    Myers, Jason K.
    Vetman, Tatiana N.
    Margolis, Brandon J.
    Jacobsen, E. Jon
    Acker, Brad A.
    Groppi, Vincent E.
    Wolfe, Mark L.
    Thornburgh, Bruce A.
    Tinholt, Paula M.
    Cortes-Burgos, Luz A.
    Walters, Rodney R.
    Hester, Matthew R.
    Seest, Eric P.
    Dolak, Lester A.
    Han, Fusen
    Olson, Barbara A.
    Fitzgerald, Laura
    Staton, Brian A.
    Raub, Thomas J.
    Hajos, Mihaly
    Hoffmann, William E.
    Li, Kai S.
    Higdon, Nicole R.
    Wall, Theron M.
    Hurst, Raymond S.
    Wong, Erik H. F.
    Rogers, Bruce N.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (24) : 8219 - 8248
  • [36] In vitro and in vivo characterization of A-796260:: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models
    Yao, B. B.
    Hsieh, G. C.
    Frost, J. M.
    Fan, Y.
    Garrison, T. R.
    Daza, A. V.
    Grayson, G. K.
    Zhu, C. Z.
    Pai, M.
    Chandran, P.
    Salyers, A. K.
    Wensink, E. J.
    Honore, P.
    Sullivan, J. P.
    Dart, M. J.
    Meyer, M. D.
    BRITISH JOURNAL OF PHARMACOLOGY, 2008, 153 (02) : 390 - 401
  • [37] POTENT AND SELECTIVE AGONIST ACTIVITY OF SR 57227A AT CENTRAL AND PERIPHERAL 5-HT3 RECEPTORS IN-VITRO AND IN-VIVO
    KEANE, PE
    BACHY, A
    HEAULME, M
    GIUDICE, A
    MICHAUD, JC
    LEFEVRE, IA
    EMERIT, MB
    SOUBRIE, P
    LEFUR, G
    JOURNAL OF NEUROCHEMISTRY, 1993, 61 : S90 - S90
  • [38] The in vitro and in vivo cardiovascular profile of ALX-0646:: a novel, highly selective 5-HT1D,1F receptor agonist
    Booth, EA
    Hennan, JK
    Barrett, TD
    Driscoll, EM
    Gupta, S
    Lindamood, C
    Lucchesi, BR
    FASEB JOURNAL, 2002, 16 (05): : A935 - A935
  • [39] F15599, a highly selective serotonin 5-HT1A receptor agonist:: in vivo profile in neurochemical and behavioural models of serotonergic activity
    Assie, M. B.
    Bardin, L.
    Depoortere, R.
    Carilla-Durand, E.
    Newman-Tancredi, A.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2006, 16 : S233 - S233
  • [40] Quantitative Structure Activity Relationship of New 7-Oxycoumarin Derivatives As Potent and Selective Monoamine Oxidase A Inhibitors
    Li, Xianchao
    Si, Hongzong
    Gao, Hua
    Zhai, Honglin
    Duan, Yunbo
    ADVANCES IN APPLIED SCIENCE AND INDUSTRIAL TECHNOLOGY, PTS 1 AND 2, 2013, 798-799 : 1109 - +
12345