Parallel synthesis of dihydropyrimidinones using Yb(III)-resin and polymer-supported scavengers under solvent-free conditions. A green chemistry approach to the Biginelli reaction

被引：199

作者：

Dondoni, A ^{[1
]}

Massi, A ^{[1
]}

机构：

[1] Univ Ferrara, Dipartmento Chim, Chim Organ Lab, I-44100 Ferrara, Italy

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 45期

关键词：

Biginelli reaction; dihydropyrimidinones; polymer-supported reagents; multicomponent reaction;

D O I：

10.1016/S0040-4039(01)01728-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of an array of 3,4-dihydropyrimidin-2-(1H)-ones using solid-supported ytterbium(III) reagent from aldehydes, 1,3-dicarbonyl compounds and urea (Biginelli reaction) under solvent-free conditions is described. Purification of each member of the library was carried out using a cocktail of acid and basic polymer-supported scavengers (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：7975 / 7978

页数：4

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