Effects of escitalopram in prevention of depression in patients with acute coronary syndrome (DECARD)

被引:30
作者
Hansen, Baiba Hedegaard [1 ]
Hanash, Jamal Abed [1 ]
Rasmussen, Alice [1 ]
Hansen, Jorgen Fischer [1 ]
Andersen, Nadia Lyhne Traerup [1 ]
Nielsen, Olav Wendelboe [1 ]
Birket-Smith, Morten [1 ]
机构
[1] Bispebjerg Hosp, Liaison Psychiat Unit, Mental Hlth Ctr Copenhagen, DK-2400 Copenhagen NV, Denmark
基金
英国医学研究理事会;
关键词
Acute coronary syndrome; Depression; Escitalopram; Prevention; ACUTE MYOCARDIAL-INFARCTION; SEROTONIN REUPTAKE INHIBITORS; HEART-DISEASE; DOUBLE-BLIND; POSTSTROKE DEPRESSION; MAJOR DEPRESSION; CARDIOVASCULAR EVENTS; CONTROLLED-TRIAL; UNSTABLE ANGINA; RISK;
D O I
10.1016/j.jpsychores.2011.07.001
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Depression is a major problem in patients after acute coronary syndrome (ACS) with negative impact on survival and quality of life. No studies have examined prevention of post-ACS depression. We examined whether treatment with escitalopram can prevent post-ACS depression. Methods: We have conducted a randomised controlled trial. Between November 2004 and December 2007, 240 patients in 2 university hospitals in Copenhagen. Denmark, with ACS were randomised. Patients were randomised to a double-blind treatment with escitalopram or matching placebo for 1 year. Main outcome measure was the incidence of ICD-10 depressive episode. Results: Of 120 patients treated with escitalopram 2 developed depression versus 10 in placebo treated group (log rank, p = 0.022). In multivariate analysis treatment with placebo and high Hamilton Depression Scale score at baseline were associated with development of depression. Patients were well matched at baseline. Conclusion: Twelve months treatment with escitalopram prevented depression in post-ACS patients. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:11 / 16
页数:6
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