N-vinyl-nitroimidazole cycloadditions:: Potential routes to nucleoside analogues

被引：10

作者：

Clayton, R ^{[1
]}

Ramsden, CA ^{[1
]}

机构：

[1] Univ Keele, Sch Chem & Phys, Lennard Jones Labs, Keele ST5 5BG, Staffs, England

来源：

SYNTHESIS-STUTTGART | 2005年 / 16期

关键词：

nitroimidazole; vinylimidazole; 1,3-dipolar cycloadditions; isoxazoline; nucleoside analogues;

D O I：

10.1055/s-2005-872083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cycloaddition reactions of 4-nitro- and 5-nitro-1-vinylimidazoles have been investigated. The cycloadducts obtained are potential intermediates for synthesis of purine nucleoside analogues via reduction to the corresponding aminomidazoles. A byproduct obtained using benzonitrile oxide as 1,3-dipolarophile has been identified as a novel tricyclic isomer 12 of the cycloadduct it.

引用

页码：2695 / 2700

页数：6

共 22 条

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