Enhanced Signaling Through the TLR9 Pathway Is Associated With Resistance to HIV-1 Infection in Chinese HIV-1-Exposed Seronegative Individuals

被引：4
|
作者：
Jiang, Junjun [1 ,2 ]
Hu, Xi [1 ]
Li, Wenwei [2 ]
Liu, Jie [1 ,2 ]
Liang, Bingyu [1 ,2 ]
Chen, Hui [1 ,2 ]
Huang, Jiegang [1 ,2 ]
Zang, Ning [2 ]
Ning, Chuanyi [1 ,2 ]
Liao, Yanyan [1 ,2 ]
Chen, Rongfeng [1 ,2 ]
Lai, Jingzhen [2 ]
Chu, Jiemei [2 ]
Pan, Peijiang [1 ,2 ]
Cui, Ping [2 ]
Tang, Qiao [1 ,2 ]
Chen, Xiu [1 ,2 ]
Liang, Hao [1 ,2 ]
Ye, Li [1 ,2 ]
机构：
[1] Guangxi Med Univ, Sch Publ Hlth, Guangxi Key Lab AIDS Prevent & Treatment, Nanning, Peoples R China
[2] Guangxi Med Univ, Guangxi Collaborat Innovat Ctr Biomed, Life Sci Inst, Nanning, Peoples R China
来源：
FRONTIERS IN IMMUNOLOGY | 2020年 / 11卷
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
HIV-1; HIV-1-exposed seronegative; innate immunity; TLR9; China; EXPOSED UNINFECTED INDIVIDUALS; SEX WORKERS; T-CELLS; ACTIVATION; RESPONSES; POLYMORPHISMS; INTERFERONS; EXPRESSION; INDUCTION; IMMUNITY;
D O I：
10.3389/fimmu.2020.01050
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Innate immunity is the first line of defense against invading pathogens and may mediate HIV-1 resistance in HIV-1-exposed seronegative (HESN) individuals. This study aims to identify components of innate immunity that confer natural HIV-1 resistance in Chinese HESN individuals. Specifically, we compared the expression levels of Toll-like receptors (TLRs) and associated pathway molecules in peripheral blood mononuclear cells (PBMCs), monocytes/macrophages, and plasma obtained from HESN and control individuals. HESN individuals had higher expression of TLR9, IRF7, IFN-alpha/beta, RANTES, and MIP-1 alpha/1 beta in PBMCs and plasma than control subjects. Upon TLR9 stimulation, significantly higher expression of TLR9 and IRF7, as well as higher production of IFN-alpha/beta, RANTES, and MIP-1 alpha/1 beta, was observed in PBMCs and monocytes/macrophages from HESN individuals than in the corresponding cells from control individuals. More importantly, both with and without TLR9 stimulation, the levels of HIV-1 replication in monocyte-derived macrophages (MDMs) from HESN individuals were significantly lower than those in MDMs from control individuals. These data suggest that increased TLR9 activity and subsequent release of antiviral factors contribute to protection against HIV-1 in HESN individuals.
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页数：11
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