New variants of E6 and E7 oncogenes of human papillomavirus type 31 identified in Northeastern Brazil

被引：20
|
作者：
Chagas, Barbara S. [1 ]
Batista, Marcus V. A. [1 ]
Guimaraes, Vilma [2 ]
Balbino, Valdir Q. [1 ]
Crovella, Sergio [1 ,3 ,4 ]
Freitas, Antonio C. [1 ,3 ]
机构：
[1] Univ Fed Pernambuco, Dept Genet, Recife, PE, Brazil
[2] Inst Integral Med Prof Fernando Figueira, Recife, PE, Brazil
[3] Univ Fed Pernambuco, Lab Immunopathol Keizo Azami, Recife, PE, Brazil
[4] Genet Serv IRCCS Burlo Garofolo, Trieste, Italy
来源：
GYNECOLOGIC ONCOLOGY | 2011年 / 123卷 / 02期
关键词：
Human papillomavirus variants; Genetic diversity; Cervical cancer; CERVICAL INTRAEPITHELIAL NEOPLASIA; HUMAN-PAPILLOMAVIRUS-16; E6; SEQUENCE VARIANTS; BINDING-SITES; RISK; PREDICTION; LESIONS; CANCER; GENE; POLYMORPHISM;
D O I：
10.1016/j.ygyno.2011.07.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective. We sought to characterize E6 and E7 oncogenes genetic variability of HPV-31 isolated from cervical scraping samples of Northeastern Brazilian women. Methods. E6 and E7 were amplified with specific primers, cloned and sequenced. The sequences obtained were aligned with the GenBank reference sequences with the aim of evaluating the possible genetic variants. Results. We identified several genetic variants in E6 and E7 sequences from HPV-31 positive women. Three nucleotide changes in E6 were described for the first time in this study. Some nucleotide changes were non-synonymous substitutions. Conclusion. The knowledge of region/country HPV specific genetic variations is relevant to understand the epidemiology and the development of effective vaccines. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：284 / 288
页数：5
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