DNA Sequence-Specific Ligands: XIV. Synthesis of Fluorescent Biologically Active Dimeric Bisbenzimidazoles DB(3,4,5,7,11)

被引：14

作者：

Ivanov, A. A. ^{[2
]}

Salyanov, V. I. ^{[1
]}

Strel'tsov, S. A. ^{[1
]}

Cherepanova, N. A. ^{[3
]}

Gromova, E. S. ^{[3
]}

Zhuze, A. L. ^{[1
]}

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Russian Acad Med Sci, Blokhin Russian Oncol Res Ctr, Res Inst Carcinogenesis, Moscow 115478, Russia

[3] Moscow MV Lomonosov State Univ, Fac Chem, Moscow 119899, Russia

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2011年 / 37卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

dimeric bisbenzimidazole; synthesis; fluorescence; CD; DNA; minor groove ligand; site-specificity; DNA topoisomerase I; inhibitor; DNA methyltransferase; MINOR-GROOVE; HOECHST-33258; MOLECULES; IN-VITRO; BINDING; METHYLTRANSFERASES; CANCER; INHIBITORS; ACIDS;

D O I：

10.1134/S1068162011040054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five fluorescent symmetrical dimeric bisbenzimidazoles DB(n) containing four 2,6-substituted benzimidazole cores and differing in the length of the oligomethylene linker between two bisbenzimidazole rings (n = 3, 4, 5, 7, 11) have been synthesized. The ability of the dimeric bisbenzimidazoles to form complexes with the double-stranded DNA has been shown by spectral methods. Upon binding to the double-stranded DNA, DB(n) are localized in the narrow groove. The data on the inhibition of the DNA methyl-transferase Dnmt3a by DB(n) indicate that dimeric bisbenzimidazoles DB(3) and DB(11) site-specifically bind to the oligonucleotide duplex.

引用

页码：472 / 482

页数：11

共 11 条

[11] DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties; genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n)
Koval, Vasiliy S.
Arutyunyan, Albert F.
Salyanov, Victor, I
Kostyukov, Alexey A.
Melkina, Olga E.
Zavilgelsky, Gennadii B.
Klimova, Regina R.
Kushch, Alla A.
Korolev, Sergey P.
Agapkina, Yulia Yu
Gottikh, Marina B.
Vaiman, Andrey V.
Rybalkina, Ekaterina Yu
Susova, Olga Yu
Zhuze, Alexei L.
BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 28 (07)

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