Depressive symptoms, vascular risk factors and mild cognitive impairment

被引：43

作者：

Panza, Francesco ^{[1
]}

D'Introno, Alessia ^{[1
]}

Colacicco, Anna M. ^{[1
]}

Capurso, Cristiano ^{[3
]}

Del Parigi, Angelo ^{[8
]}

Caselli, Richard J. ^{[9
]}

Todarello, Orlando ^{[2
]}

Pellicani, Vincenza ^{[2
]}

Santamato, Andrea ^{[4
]}

Scapicchio, Pierluigi ^{[5
]}

Maggi, Stefania ^{[7
]}

Scafato, Emanuele ^{[6
]}

Gandin, Claudia ^{[6
]}

Capurso, Antonio ^{[1
]}

Solfrizzi, Vincenzo ^{[1
]}

机构：

[1] Univ Bari, Memory Unit, Ctr Aging Brain, Dept Geriatr, IT-70124 Bari, Italy

[2] Univ Bari, Dept Neurol & Psychiat Sci, IT-70124 Bari, Italy

[3] Univ Foggia, Dept Geriatr, Foggia, Italy

[4] Univ Foggia, Dept Phys Med & Rehabil, Foggia, Italy

[5] Univ Cattolica Sacro Cuore, CNESPS, Ist Super Sanita, I-00168 Rome, Italy

[6] Natl Ctr Epidemiol, CNESPS, Ist Super Sanita, I-00168 Rome, Italy

[7] CNR, CNR, Ctr Aging, Padua, Italy

[8] NIDDKD, NIH, Phoenix, AZ USA

[9] Mayo Clin, Dept Neurol, Scottsdale, AZ USA

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2008年 / 25卷 / 04期

关键词：

dementia; epidemiology; mild cognitive impairment; depression; vascular risk factors;

D O I：

10.1159/000119522

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aims: We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI. Methods: A total of 2,963 individuals from a sample of 5,632 65-to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85 -1.84, chi(2) = 1.30, p < 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI. Conclusion: In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI. Copyright (C) 2008 S. Karger AG, Basel.

引用

页码：336 / 346

页数：11

共 61 条

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