Depressive symptoms, vascular risk factors and mild cognitive impairment

被引:43
作者
Panza, Francesco [1 ]
D'Introno, Alessia [1 ]
Colacicco, Anna M. [1 ]
Capurso, Cristiano [3 ]
Del Parigi, Angelo [8 ]
Caselli, Richard J. [9 ]
Todarello, Orlando [2 ]
Pellicani, Vincenza [2 ]
Santamato, Andrea [4 ]
Scapicchio, Pierluigi [5 ]
Maggi, Stefania [7 ]
Scafato, Emanuele [6 ]
Gandin, Claudia [6 ]
Capurso, Antonio [1 ]
Solfrizzi, Vincenzo [1 ]
机构
[1] Univ Bari, Memory Unit, Ctr Aging Brain, Dept Geriatr, IT-70124 Bari, Italy
[2] Univ Bari, Dept Neurol & Psychiat Sci, IT-70124 Bari, Italy
[3] Univ Foggia, Dept Geriatr, Foggia, Italy
[4] Univ Foggia, Dept Phys Med & Rehabil, Foggia, Italy
[5] Univ Cattolica Sacro Cuore, CNESPS, Ist Super Sanita, I-00168 Rome, Italy
[6] Natl Ctr Epidemiol, CNESPS, Ist Super Sanita, I-00168 Rome, Italy
[7] CNR, CNR, Ctr Aging, Padua, Italy
[8] NIDDKD, NIH, Phoenix, AZ USA
[9] Mayo Clin, Dept Neurol, Scottsdale, AZ USA
关键词
dementia; epidemiology; mild cognitive impairment; depression; vascular risk factors;
D O I
10.1159/000119522
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Aims: We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI. Methods: A total of 2,963 individuals from a sample of 5,632 65-to 84-year-old subjects were cognitively and functionally evaluated at the 1st and 2nd surveys of the Italian Longitudinal Study on Aging, a prospective cohort study with a 3.5-year follow-up. MCI and dementia were classified using current clinical criteria. Depressive symptoms were measured with the Geriatric Depression Scale. Results: Among the 2,963 participants, 139 prevalent MCI cases were diagnosed at the 1st survey. During the 3.5-year follow-up, 105 new events of MCI were diagnosed. We did not observe any significant association between depressive symptoms and incident MCI (RR = 1.25, 95% CI = 0.85 -1.84, chi(2) = 1.30, p < 0.25). No sociodemographic variables or vascular risk factors modified the relationship between depressive symptoms and incident MCI. Conclusion: In our population, depressive symptoms were not associated with the rate of incident MCI. Our findings did not support a role of sociodemographic variables or vascular risk factors in the link between depressive symptoms and incident MCI. Copyright (C) 2008 S. Karger AG, Basel.
引用
收藏
页码:336 / 346
页数:11
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