NUT carcinoma presenting in the palate - a case report

被引：4

作者：

Bjornstrup, Libana Raffoul ^{[1
]}

Reibel, Jesper ^{[2
]}

Kiss, Katalin ^{[3
]}

Schioedt, Morten ^{[4
]}

机构：

[1] Rigshosp Copenhagen, Resident Oral & Maxillofacial Surg, DDS, Copenhagen, Denmark

[2] Univ Copenhagen, Dept Oral Pathol, Copenhagen, Denmark

[3] Rigshosp, Dept Pathol, Copenhagen, Denmark

[4] Rigshosp, Dept Oral & Maxillofacial Surg, Copenhagen, Denmark

来源：

APMIS | 2017年 / 125卷 / 10期

关键词：

NUT carcinoma; BRD4-NUT; palate; oral manifestations; oral cavity; MIDLINE CARCINOMA; FEATURES; SERIES;

D O I：

10.1111/apm.12710

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NUT carcinomas (NC) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis (NUT) located on chromosome 15q14. This article presents a case of a 60-year-old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. A review of the literature did not reveal earlier cases presenting in the palate. In order to improve early diagnosis it is suggested to perform immunohistochemical testing for NUT in all poorly differentiated carcinomas without glandular differentiation arising in the chest, and head and neck (Clin Cancer Res, 18, 2012, 5773).

引用

页码：933 / 936

页数：4

共 13 条

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