共 88 条
The Potential Role of Probiotics in the Management of Childhood Autism Spectrum Disorders
被引:114
作者:
Critchfield, J. William
[2
]
van Hemert, Saskia
[1
]
Ash, Michael
[3
]
Mulder, Linda
[1
]
Ashwood, Paul
[2
]
机构:
[1] Winclove Bio Ind, R&D Dept, NL-1032 LB Amsterdam, Netherlands
[2] Univ Calif Davis, Dept Med Microbiol & Immunol, Davis, CA 95616 USA
[3] Integrat Hlth Consulting, Newton Abbot TQ12 4SG, Devon, England
关键词:
IRRITABLE-BOWEL-SYNDROME;
LYMPHOCYTE CYTOKINE PROFILES;
IN-VIVO;
GASTROINTESTINAL SYMPTOMS;
DOUBLE-BLIND;
IMMUNOMODULATORY PROPERTIES;
INTESTINAL BARRIER;
REGRESSIVE AUTISM;
IMMUNE ACTIVATION;
PROPIONIC-ACID;
D O I:
10.1155/2011/161358
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
Gastrointestinal (GI) dysfunction has been reported in a substantial number of children with autism spectrum disorders (ASD). Activation of the mucosal immune response and the presence of abnormal gut microbiota are repeatedly observed in these children. In children with ASD, the presence of GI dysfunction is often associated with increased irritability, tantrums, aggressive behaviour, and sleep disturbances. Moreover, modulating gut bacteria with short-term antibiotic treatment can lead to temporary improvement in behavioral symptoms in some individuals with ASD. Probiotics can influence microbiota composition and intestinal barrier function and alter mucosal immune responses. The administration of probiotic bacteria to address changes in the microbiota might, therefore, be a useful novel therapeutic tool with which to restore normal gut microbiota, reduce inflammation, restore epithelial barrier function, and potentially ameliorate behavioural symptoms associated with some children with ASD. In this review of the literature, support emerges for the clinical testing of probiotics in ASD, especially in the context of addressing GI symptoms.
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