The role of cyclooxygenase-2 in breast cancer: review

被引：98

作者：

Singh-Ranger, Gurpreet ^{[2
]}

Salhab, Mohamed ^{[2
]}

Mokbel, Kefah ^{[1
,2
]}

机构：

[1] Princess Grace Hosp, London Breast Inst, London W1M 3FD, England

[2] St Georges Univ London, London, England

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2008年 / 109卷 / 02期

关键词：

COX-2; breast cancer; prevention; treatment; DCIS; NSAIDs;

D O I：

10.1007/s10549-007-9641-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit.

引用

页码：189 / 198

页数：10

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