The role of cyclooxygenase-2 in breast cancer: review

被引：99
作者：
Singh-Ranger, Gurpreet [2 ]
Salhab, Mohamed [2 ]
Mokbel, Kefah [1 ,2 ]
机构：
[1] Princess Grace Hosp, London Breast Inst, London W1M 3FD, England
[2] St Georges Univ London, London, England
来源：
BREAST CANCER RESEARCH AND TREATMENT | 2008年 / 109卷 / 02期
关键词：
COX-2; breast cancer; prevention; treatment; DCIS; NSAIDs;
D O I：
10.1007/s10549-007-9641-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
There is a growing body of evidence that COX-2 expression s a fundamental step in breast cancer pathogenesis acting through prostaglandin-dependent and independent mechanisms. Epidemiological studies suggest that NSAIDs confer a moderate degree of benefit against breast cancer. However further work is required to establish how this enzyme system can be best manipulated for therapeutic benefit.
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收藏
页码：189 / 198
页数：10
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