Assessment of gonadotrophin suppression in girls treated with GnRH analogue for central precocious puberty; validity of single luteinizing hormone measurement after leuprolide acetate injection

被引：20

作者：

Demirbilek, Huseyin ^{[1
]}

Alikasifoglu, Ayfer ^{[1
]}

Gonc, Nazli E. ^{[1
]}

Ozon, Alev ^{[1
]}

Kandemir, Nurgun ^{[1
]}

机构：

[1] Hacettepe Univ, Sch Med, Div Pediat Endocrinol, TR-06100 Ankara, Turkey

来源：

CLINICAL ENDOCRINOLOGY | 2012年 / 76卷 / 01期

关键词：

DEPOT LEUPROLIDE; CHILDREN; THERAPY; SAMPLE;

D O I：

10.1111/j.1365-2265.2011.04185.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective Intravenous GnRH stimulation test has often been used as gold standard test for the evaluation of hypothalamicpituitarygonadal axis in the diagnosis of central precocious puberty (CPP) and in the assessment of pubertal suppression. However, this test is time-consuming, costly and uncomfortable for the patients. We aimed to analyse the validity of single LH sample 90 min after GnRH analogue (GnRHa) administration in the evaluation of gonadotrophin suppression during CPP therapy and to determine a cut-off level for LH indicating adequate suppression.

引用

页码：126 / 130

页数：5

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