Role of Circular RNAs in the Regulation of Immune Cells in Response to Cancer Therapies

被引：11

作者：

Carlos-Reyes, Angeles ^{[1
]}

Romero-Garcia, Susana ^{[2
]}

Contreras-Sanzon, Estefania ^{[3
]}

Ruiz, Victor ^{[4
]}

Prado-Garcia, Heriberto ^{[1
]}

机构：

[1] Inst Nacl Enfermedades Respiratorias, Dept Enfermedades Cron Degenerativas, Lab Oncoinmunobiol, Mexico City, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Ciencias, Mexico City, DF, Mexico

[3] Univ Autonoma Ciudad Mexico, Posgrado Ciencias Genom, Mexico City, DF, Mexico

[4] Inst Nacl Enfermedades, Lab Biol Mol, Mexico City, DF, Mexico

来源：

FRONTIERS IN GENETICS | 2022年 / 13卷

关键词：

CircRNAs; immune cells; cancer; T cells; immunotherapy; resistance to therapy; MECHANISMS;

D O I：

10.3389/fgene.2022.823238

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Circular RNAs (CircRNAs) are a class of small endogenous noncoding RNA that are formed by means of either the spliceosome or lariat-type splicing. CircRNAs have multiple regulatory functions and have been detected in different cell types, like normal, tumor and immune cells. CircRNAs have been suggested to regulate T cell functions in response to cancer. CircRNAs can enter into T cells and promote the expression of molecules that either trigger antitumoral responses or promote suppression and the consequent evasion to the immune response. Additionally, circRNAs may promote tumor progression and resistance to anticancer treatment in different types of neoplasias. In this minireview we discuss the impact of circRNAs and its function in the regulation of the T-cells in immune response caused by cancer therapies.

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