Natural resistance against infections: focus on COVID-19

被引:14
|
作者
Netea, Mihai G. [1 ,2 ,3 ]
Dominguez-Andres, Jorge [1 ,2 ]
van de Veerdonk, Frank L. [1 ,2 ]
van Crevel, Reinout [1 ,2 ,4 ]
Pulendran, Bali [5 ,6 ]
van der Meer, Jos W. M. [1 ,2 ]
机构
[1] Radboud Univ Nijmegen Med Ctr, Dept Internal Med, Nijmegen, Netherlands
[2] Radboud Univ Nijmegen Med Ctr, Radboud Ctr Infect Dis, Nijmegen, Netherlands
[3] Univ Bonn, Life & Med Sci Inst, Dept Immunol & Metab, Bonn, Germany
[4] Univ Oxford, Nuffield Dept Med, Ctr Trop Med & Global Hlth, Oxford, England
[5] Stanford Univ, Sch Med, Inst Immunol Transplantat & Infect Dis, Dept Pathol, Stanford, CA 94305 USA
[6] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA
基金
美国国家卫生研究院; 欧洲研究理事会;
关键词
IMMUNITY; TOLERANCE; HIV;
D O I
10.1016/j.it.2021.12.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Not all individuals exposed to a pathogen develop illness: some are naturally resistant whereas others develop an asymptomatic infection. Epidemiological studies suggest that there is similar variability in susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We propose that natural resistance is part of the disease history in some individuals exposed to this new coronavirus. Epidemiological arguments for natural resistance to SARS-CoV-2 are the lower seropositivity of children compared to adults, studies on closed environments of ships with outbreaks, and prevalence studies in some developing countries. Potential mechanisms of natural resistance include host genetic variants, viral interference, cross-protective natural antibodies, T cell immunity, and highly effective innate immune responses. Better understanding of natural resistance can help to advance preventive and therapeutic measures against infections for improved preparedness against potential future pandemics.
引用
收藏
页码:106 / 116
页数:11
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