Extracellular Vesicles: A Prevalent Tool for Microbial Gene Delivery?

被引：5
作者：
Ben-Hur, Sharon [1 ]
Biton, Mirit [1 ]
Regev-Rudzki, Neta [1 ]
机构：
[1] Weizmann Inst Sci, Dept Biomol Sci, Fac Biochem, Rehovot, Israel
来源：
PROTEOMICS | 2019年 / 19卷 / 1-2期
基金：
欧洲研究理事会; 以色列科学基金会;
关键词：
extracellular vesicles; horizontal gene transfer; MEMBRANE-VESICLES; MEDIATED TRANSFER; DNA; EXOSOMES; DEOXYRIBONUCLEASE; IDENTIFICATION; COMMUNICATION; MICROVESICLES; BIOGENESIS; BACTERIA;
D O I：
10.1002/pmic.201800170
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Genetic plasticity of prokaryotic microbial communities is largely dependent on the ongoing exchange of genetic determinants by Horizontal Gene Transfer (HGT). HGT events allow beneficial genetic transitions to occur throughout microbial life, thus promoting adaptation to changing environmental conditions. Here, the significance of secreted vesicles in mediating HGT between microorganisms is discussed, while focusing on the benefits gained by vesicle-mediated gene delivery and its occurrence under different environmental cues. The potential use of secreted DNA-harboring vesicles as a mechanism of currently unresolved HGT events in eukaryotic microbes is further discussed.
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页数：4
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