Humoral immune response in healthcare workers after two doses of a BNT162b2 mRNA vaccine in Yucatan, Mexico

被引：2

作者：

Figueroa-Hurtado, Esperanza ^{[1
]}

Ortiz-Farias, Diana Lizbeth ^{[1
]}

Sada-Ovalle, Isabel ^{[2
]}

Maldonado-Ortiz, Sandra Yareth ^{[3
]}

Valdivieso-Jimenez, Jorge Arturo ^{[4
]}

Cortes-Telles, Arturo ^{[1
]}

机构：

[1] Hosp Reg Alta Especialidad Peninsula Yucatan, Dept Neumol & Cirugia Torax, Calle 7-433 20 22,Fraccionamiento Altabrisa, Merida 97133, Mexico

[2] Univ Autonoma San Luis Potosi, Fac Med, Dept Fisiol, San Luis Potosi, San Luis Potosi, Mexico

[3] Hosp Reg Alta Especialidad Peninsula Yucatan, Unidad Cuidados Intensivos, Merida, Mexico

[4] Hosp Reg Alta Especialidad Peninsula Yucatan, Unidad Atenc COVID19, Merida, Mexico

来源：

RESPIROLOGY CASE REPORTS | 2022年 / 10卷 / 04期

关键词：

COVID-19; humoral immunity; immune response; vaccine;

D O I：

10.1002/rcr2.920

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as the host immune response after vaccination and viral infection have shown to be highly heterogeneous. This is a case series study analysing humoral immune response and vaccination side effects after two doses of a BNT162b2 mRNA among healthcare workers (HCWs) in Mexico. All participants were scheduled for their two doses of mRNA BNT162b2 vaccine and provided information through a questionnaire: demographic characteristics, antibody serum titres and vaccination-related side effects. Blood samples were obtained for serology testing after the first and second doses of vaccine. No serious adverse effects due to vaccination were reported; nonetheless, non-medical HCWs reported more side effects after the second dose. The previous infection with SARS-CoV-2 boosted immune response after receiving the first vaccination (roughly 30 times higher than those without previous infection); nonetheless, after the second dose, the immune response did not show a higher titre as might be expected.

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