Polymer Brushes Interfacing Blood as a Route Toward High Performance Blood Contacting Devices

被引：61

作者：

Surman, Frantisek ^{[1
]}

Riedel, Tomas ^{[1
]}

Bruns, Michael ^{[2
]}

Kostina, Nina Yu. ^{[1
]}

Sedlakova, Zdenka ^{[1
]}

Rodriguez-Emmenegger, Cesar ^{[1
]}

机构：

[1] Acad Sci Czech Republ, Inst Macromol Chem, Vvi, CR-16206 Prague, Czech Republic

[2] KIT, KNMF, IAM, D-76344 Eggenstein Leopoldshafen, Germany

来源：

MACROMOLECULAR BIOSCIENCE | 2015年 / 15卷 / 05期

关键词：

blood compatibility; blood plasma; non-fouling; surfaces; proteins; SELF-ASSEMBLED MONOLAYERS; TRANSFER RADICAL POLYMERIZATION; PROTEIN-RESISTANT SURFACES; CELL-ADHESION; PLASMA; COAGULATION; CHEMISTRY; FUNCTIONALIZATION; MACROMOLECULES; METHACRYLATE;

D O I：

10.1002/mabi.201400470

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the current study, well-defined polymer brushes are shown as an effective surface modification to resist the adhesion of whole blood and its components. Poly[oligo(ethylene glycol)methylether methacrylate] (poly(MeOEGMA)), poly(hydroxyethyl methacrylate) (poly(HEMA)), poly[N-(2-hydroxypropyl) methacrylamide] (poly(HPMA)), and poly(carboxybetaine acrylamide) (poly(CBAA)) brushes were grown by surface initiated atom transfer radical polymerization (SI-ATRP) and subsequently characterized by Fourier-transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), dynamic contact angle measurements, atomic force microscopy (AFM), and surface plasmon resonance (SPR) spectroscopy. All brushes decreased the fouling from blood plasma over 95% and prevented the adhesion of platelets, erythrocytes, and leukocytes as evidenced by SPR and SEM measurements.

引用

页码：636 / 646

页数：11

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